Immune responses of pigs to commercialized emulsion FMD vaccines and live virus challenge

被引：9

作者：

Chen, S. P.

Lee, M. C.

Sun, Y. F.

Cheng, I. C.

Yang, P. C.

Lin, Y. L.

Jong, M. H.

Robertson, I. D.

Edwards, J. R.

Ellis, T. M. ^{[1
]}

机构：

[1] Murdoch Univ, Sch Vet & Biomed Sci, Div Hlth Sci, Murdoch, WA 6150, Australia

[2] Anim Technol Inst Taiwan, Div Anim Sci, Miaoli, Taiwan

[3] Coll Agr, Anim Hlth Res Inst, Tamsui, Taipei Cty, Taiwan

来源：

VACCINE | 2007年 / 25卷 / 22期

关键词：

foot-and-mouth disease; diagnosis; neutralizing antibodies; vaccines; non-structural proteins; ELISA (enzyme linked immunosorbent assay);

D O I：

10.1016/j.vaccine.2007.03.019

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

The immune response to structural and non-structural proteins (NSPs) was studied on sequential serum samples in swine from O/Taiwan/97 FMDV challenge studies, outbreaks and after vaccination. The results showed that pigs vaccinated with a commercial vaccine prior to or after infection maintained high neutralizing antibody titers with gradual decline from peak titers over the duration of this study. However, neutralizing antibody titers in non-vaccinated pigs only reached moderate levels 2-4 weeks post infection and remained low thereafter. For the 3B and 3ABC NSP antibody ELISA responses, there were gradually decreasing levels of NSP antibody over time. In multiple vaccinations, all pigs showed significant increases in neutralizing antibodies after booster vaccination. For the 313 NSP antibody ELISA after vaccination, the mean SIP ratios for pigs vaccinated with all three FMD vaccines were all below the 0.23 cut-off value set by the manufacture, but some sera from individual vaccinated pigs gave results above this cut-off after primary or secondary vaccination. However, with the 3ABC NSP antibody ELISA, all sera from vaccinated pigs had negative results for NSP antibody for all time points. (C) 2007 Elsevier Ltd. All rights reserved.

引用

页码：4464 / 4469

页数：6