14th International Congress on Antiphospholipid Antibodies Task Force. Report on antiphospholipid syndrome laboratory diagnostics and trends

被引：199

作者：

Bertolaccini, Maria Laura ^{[1
]}

Amengual, Olga ^{[2
]}

Andreoli, Laura ^{[3
,4
]}

Atsumi, Tatsuya ^{[2
]}

Chighizola, Cecilia B. ^{[5
,6
]}

Forastiero, Ricardo ^{[7
]}

De Groot, Philip ^{[8
]}

Lakos, Gabriella ^{[9
]}

Lambert, Marc ^{[10
,11
]}

Meroni, Pierluigi ^{[6
,12
]}

Ortel, Thomas L. ^{[13
]}

Petri, Michelle ^{[14
]}

Rahman, Anisur ^{[15
]}

Roubey, Robert ^{[16
,17
]}

Sciascia, Savino ^{[1
]}

Snyder, Melissa ^{[18
]}

Tebo, Anne E. ^{[19
]}

Tincani, Angela ^{[3
,4
]}

Willis, Rohan ^{[20
]}

机构：

[1] Kings Coll London, Sch Med, Rayne Inst, Graham Hughes Lupus Res Lab,Lupus Res Unit, London SE1 7EH, England

[2] Hokkaido Univ, Sch Med, Dept Internal Med 2, Sapporo, Hokkaido 060, Japan

[3] Univ Brescia, Dept Clin & Expt Sci, I-25121 Brescia, Italy

[4] Spedali Civil Brescia, Rheumatol & Clin Immunol Unit, I-25125 Brescia, Italy

[5] Univ Milan, Dept Clin Sci & Community Hlth, Div Rheumatol, I-20122 Milan, Italy

[6] Ist Auxol Italiano, Expt Lab Immunorheumatol, Milan, Italy

[7] Favaloro Univ, Univ Hosp, Favaloro Fdn, Dept Physiol,Div Hematol Thrombosis & Haemostasis, Buenos Aires, DF, Argentina

[8] Univ Med Ctr, Dept Clin Chem & Haematol, Utrecht, Netherlands

[9] INOVA Diagnost, San Diego, CA USA

[10] Hop Claude Huriez, Ctr Hosp Reg, Serv Med Interne, Lille, France

[11] Univ Lille, Lille, France

[12] Univ Milan, Dept Clin Sci & Community Hlth, I-20122 Milan, Italy

[13] Duke Univ, Med Ctr, Dept Med, Lab Based Res,Clin Coagulat Lab, Durham, NC 27710 USA

[14] Johns Hopkins Univ, Sch Med, Dept Med, Baltimore, MD 21205 USA

[15] UCL, Ctr Rheumatol, Div Med, London, England

[16] Univ N Carolina, Div Rheumatol Allergy & Immunol, Chapel Hill, NC USA

[17] Univ N Carolina, Thurston Arthrit Res Ctr, Chapel Hill, NC USA

[18] Mayo Clin, Dept Lab Med & Pathol, Rochester, MN USA

[19] Univ Utah, ARUP, Sch Med, Inst Clin & Expt Pathol, Salt Lake City, UT USA

[20] Univ Texas Med Branch, Dept Internal Med, Div Rheumatol, Antiphospholipid Standardizat Lab, Galveston, DC USA

来源：

AUTOIMMUNITY REVIEWS | 2014年 / 13卷 / 09期

关键词：

aCL; IgA; Antiprothrombin antibodies; Domain I; Lupus anticoagulant; Risk; SYSTEMIC-LUPUS-ERYTHEMATOSUS; ANTI-BETA-2; GLYCOPROTEIN-I; ANTI-PHOSPHATIDYLSERINE/PROTHROMBIN ANTIBODIES; INDEPENDENT RISK-FACTOR; APL TESTS REPORT; DOMAIN-I; ANTICARDIOLIPIN ANTIBODIES; ANTI-BETA(2)-GLYCOPROTEIN I; CLINICAL-SIGNIFICANCE; ANTIPHOSPHATIDYLETHANOLAMINE ANTIBODIES;

D O I：

10.1016/j.autrev.2014.05.001

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Current classification criteria for definite Antiphospholipid Syndrome CAPS) require the use of three laboratory assays to detect antiphospholipid antibodies (aCL, anti-beta 2GPI and LA) in the presence of at least one of the two major clinical manifestations (i.e. thrombosis or pregnancy morbidity) of the syndrome. However, several other autoantibodies shown to be directed to other proteins or their complex with phospholipids have been proposed to be relevant to APS but their clinical utility and their diagnostic value remains elusive. This report summarizes the findings, conclusions and recommendations of the "APS Task Force 3-Laboratory Diagnostics and Trends" meeting that took place during the 14th International Congress on Antiphospholipid Antibodies (APLA 2013, September 18-21, Rio de Janeiro, Rj, Brazil). (c) 2014 Elsevier B.V. All rights reserved.

引用

页码：917 / 930

页数：14

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