Efficient co-crystal screening using solution-mediated phase transformation

被引:181
作者
Zhang, Geoff G. Z. [1 ]
Henry, Rodger F.
Borchardt, Thomas B.
Lou, Xiaochun
机构
[1] Abbott Labs, Global Pharmaceut R&D, Solid State Sci, N Chicago, IL 60064 USA
[2] Abbott Labs, Global Pharmaceut R&D, Struct Chem, N Chicago, IL 60064 USA
[3] Abbott Labs, Global Pharmaceut R&D, Solid State Chem, N Chicago, IL 60064 USA
关键词
co-crystal; screening; physical stability; solution-mediated phase transformation;
D O I
10.1002/jps.20949
中图分类号
R914 [药物化学];
学科分类号
100701 ;
摘要
have extended the established physical stability treatment for hydrates/ solvates to co-crystals with solid co-crystal formers. Based on the proposed treatment, a suspension/slurry screening technique is developed and tested in sixteen pharmaceutical co-crystal systems with success. The theoretical treatment and the practical screening technique should benefit the researchers in the field of co-crystallization in improving the screening efficiency. (c) 2007 Wiley-Liss, Inc. and the American Pharmacists Association J Pharm Sci 96:990-995, 2007.
引用
收藏
页码:990 / 995
页数:6
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