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Functional consequences of histone modifications

被引：251
作者：
Iizuka, M
Smith, MM
机构：
[1] Univ Virginia, Dept Microbiol, Charlottesville, VA 22908 USA
[2] Univ Virginia, Ctr Canc, Charlottesville, VA 22908 USA
来源：
CURRENT OPINION IN GENETICS & DEVELOPMENT | 2003年 / 13卷 / 02期
关键词：
D O I：
10.1016/S0959-437X(03)00020-0
中图分类号：
Q2 [细胞生物学];
学科分类号：
071009 ; 090102 ;
摘要：
Covalent modifications of the histone proteins have well-known roles in gene expression. Experiments reported during the past year have extended this paradigm to include roles for histone acetylation and phosphorylation in DNA double-strand break repair. In addition, new results now provide a definitive example of an acetylation histone code, whereas others reveal the workings of a charge patch mechanism. Finally, exciting research has identified new modifications, complex modification cascades, and functional links to DNA methylation and RNA interference pathways.
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页码：154 / 160
页数：7
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