Nuclear expression of YB-1 protein correlates with P-glycoprotein expression in human breast carcinoma

被引：45

作者：

Saji, H

Toi, M

Saji, S

Koike, M

Kohno, K

Kuwano, M

机构：

[1] Tokyo Metropolitan Komagome Hosp, Bunkyo Ku, Tokyo 1138677, Japan

[2] Tokyo Metropolitan Komagome Hosp, Dept Pathol, Tokyo, Japan

[3] Univ Occupat & Environm Hlth, Dept Biol Mol, Kitakyushu, Fukuoka, Japan

[4] Kyushu Univ, Sch Med, Dept Biochem, Fukuoka, Japan

来源：

CANCER LETTERS | 2003年 / 190卷 / 02期

关键词：

YB-1; P-glycoprotein; multi-drug resistance; estrogen receptor; PgR; breast carcinoma;

D O I：

10.1016/S0304-3835(02)00590-6

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Drug resistance is a common clinical problem in cancer treatment. The overexpression of P-glycoprotein appears to be closely associated with multi-drug resistance to anticancer agents. YB-1 binds to the Y-box in the promoter region of MDR1, which encodes P-glycoprotein. We evaluated the correlation between nuclear YB-1 and P-glycoprotein expression and other molecules, such as hormonal receptors, angiogenic factors, immune factors, and methalloprotease in 63 human breast cancers. Nuclear YB-1 expression had a significant correlation with P-glycoprotein and PgR expression, and also with CD68 grade, concerning accumulation of tumor associated macrophages. This series did not demonstrate P-glycoprotein and nuclear YB-1 expression might be one of the useful prognostic marker of breast cancer. (C) 2002 Elsevier Science Ireland Ltd. All rights reserved.

引用

页码：191 / 197

页数：7

共 24 条

[1] GENERATION OF A DRUG-RESISTANCE PROFILE BY QUANTITATION OF MDR-1/P-GLYCOPROTEIN IN THE CELL-LINES OF THE NATIONAL-CANCER-INSTITUTE ANTICANCER DRUG SCREEN [J].