Regulatory mechanisms of microRNAs involvement in cancer: the strange case of Dr Jekyll and Mr Hyde

被引:125
作者
Fabbri, Muller
Ivan, Mircea
Cimmino, Amelia
Negrini, Massimo
Calin, George A.
机构
[1] Ohio State Univ, Ctr Comprehens Canc, Columbus, OH 43210 USA
[2] Tufts Univ, New England Med Ctr, Mol Oncol Res Inst, Boston, MA 02111 USA
[3] Univ Naples 2, Sch Med, Dept Biochem & Biophys F Cedrangolo, Naples, Italy
[4] Univ Ferrara, Dept Expt & Diagnost Med, I-44100 Ferrara, Italy
[5] Univ Ferrara, Interdept Ctr Canc Res, I-44100 Ferrara, Italy
[6] Univ Texas, MD Anderson Canc Ctr, Dept Canc Genet, Houston, TX 77030 USA
[7] Univ Texas, MD Anderson Canc Ctr, Dept Expt Therapeut, Houston, TX 77030 USA
关键词
apoptosis; cell proliferation; diagnosis; microRNAs; oncogene; prognosis; tumour suppressor;
D O I
10.1517/14712598.7.7.1009
中图分类号
Q81 [生物工程学(生物技术)]; Q93 [微生物学];
学科分类号
071005 ; 0836 ; 090102 ; 100705 ;
摘要
MicroRNAs (miRNAs) are 19 - 24 nucleoticle noncoding RNAs that regulate the translation and degradation of target mRNAs and are extensively involved in human cancers. One unexpected conclusion of the profiling and functional studies in tumourigenesis is that some miRNAs behave in cancer cells in a dual mode, resembling the 'Dr Jekyll and Mr Hyde' story, which centers on a conception of humanity as dual in nature. The authors and others have found that onco-miRNAs and suppressor-miRNAs can represent two different looks of the same gene, behaving as oncogenes or tumour suppressors depending on tissue type and specific targets. In this review, the authors analyse the regulatory mechanisms of the main miRNA genes involved in human tumourigenesis.
引用
收藏
页码:1009 / 1019
页数:11
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