Diacylglycerol kinase

被引:76
作者
Sakane, F [1 ]
Kanoh, H [1 ]
机构
[1] Sapporo Med Univ, Sch Med, Dept Biochem, Sapporo, Hokkaido 060, Japan
关键词
diacylglycerol kinase; phosphalidic acid; signal transduction;
D O I
10.1016/S1357-2725(97)00037-X
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
Recent observations suggest that diacylglycerol kinase (DGK) is one of the key enzymes involved in the regulation of signal transduction. It attenuates protein kinase C activity and cell cycle progression of T-lymphocytes, through controlling the intracellular levels of the second messengers, diacylglycerol and phosphatidic acid. To date, eight DGK isozymes containing characteristic zinc finger structures in common have been identified. Type I DGKs (alpha, beta and gamma) contain EF-hand motifs that contribute to the calcium-dependent activities of this type of DGK. A pleckstrin homology and/or an EPH C-terminal tail homology domains are found in type II isozymes (DGK delta and eta). DGK epsilon represents a third type of DGK that selectively phosphorylates arachidonate-containing diacylglycerol, DGK zeta (type IV) and DGK theta (type V) contain four tandem ankyrin repeats and a Ras-associating domain, respectively. (C) 1997 Elsevier Science Ltd.
引用
收藏
页码:1139 / 1143
页数:5
相关论文
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