CRISPR interference: RNA-directed adaptive immunity in bacteria and archaea

被引：685

作者：

Marraffini, Luciano A. ^{[1
]}

Sontheimer, Erik J. ^{[1
]}

机构：

[1] Northwestern Univ, Dept Biochem Mol Biol & Cell Biol, Evanston, IL 60208 USA

来源：

NATURE REVIEWS GENETICS | 2010年 / 11卷 / 03期

基金：

美国国家卫生研究院;

关键词：

THERMUS-THERMOPHILUS HB8; COMPLETE GENOME SEQUENCE; HORIZONTAL GENE-TRANSFER; MYCOBACTERIUM-TUBERCULOSIS COMPLEX; RESISTANT STAPHYLOCOCCUS-AUREUS; PROVIDES ACQUIRED-RESISTANCE; SULFOLOBUS-SOLFATARICUS P2; SHORT PALINDROMIC REPEATS; RAY CRYSTAL-STRUCTURE; YERSINIA-PESTIS;

D O I：

10.1038/nrg2749

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

Sequence-directed genetic interference pathways control gene expression and preserve genome integrity in all kingdoms of life. The importance of such pathways is highlighted by the extensive study of RNA interference (RNAi) and related processes in eukaryotes. In many bacteria and most archaea, clustered, regularly interspaced short palindromic repeats (CRISPRs) are involved in a more recently discovered interference pathway that protects cells from bacteriophages and conjugative plasmids. CRISPR sequences provide an adaptive, heritable record of past infections and express CRISPR RNAs - small RNAs that target invasive nucleic acids. Here, we review the mechanisms of CRISPR interference and its roles in microbial physiology and evolution. We also discuss potential applications of this novel interference pathway.

引用

页码：181 / 190

页数：10

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