Controlled release from directly compressible theophylline buccal tablets

被引：52

作者：

Boyapally, Harikrishna ^{[1
]}

Nukala, Ravi Kumar ^{[1
]}

Bhujbal, Pranav ^{[1
]}

Douroumis, Dennis ^{[1
]}

机构：

[1] Univ Greenwich, Sch Sci, Chatham ME4 4TB, Kent, England

来源：

COLLOIDS AND SURFACES B-BIOINTERFACES | 2010年 / 77卷 / 02期

关键词：

Buccal tablets; Direct compression; Controlled release; Bioadhesion; Kinetic models; IN-VIVO EVALUATION; DRUG-DELIVERY; ADHESIVE TABLETS; DISSOLUTION; FORMULATION; SYSTEMS; OPTIMIZATION; PLATFORMS; POLYMERS; MATRICES;

D O I：

10.1016/j.colsurfb.2010.01.031

中图分类号：

Q6 [生物物理学];

学科分类号：

071011 ;

摘要：

The aim of the current study was the development of theophylline buccal adhesive tablets using direct compression. Buccal adhesive formulations were developed using a water soluble resin with various combinations of mucoadhesive polymers. The prepared theophylline tablets were evaluated for tensile strength, swelling capacity and ex vivo mucoadhesion performance. Ex vivo mucoadhesion was assessed using porcine gingival tissue and the peak detachment forces were found to be suitable for a buccal adhesive tablet with a maximum of 1.5 N approximately. The effect of formulation composition on the release pattern was also investigated. Most formulations showed theophylline controlled release profiles depended on the grade and polymer ratio. The release mechanisms were found to fit Peppas' kinetic model over a period of 5 h. In general the majority of the developed formulations presented suitable adhesion and controlled drug release. (C) 2010 Elsevier B.V. All rights reserved.

引用

页码：227 / 233

页数：7

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