Effects of a psychostimulant drug Sydnocarb on rat brain dopaminergic transmission in vivo

被引:14
作者
Gainetdinov, RR [1 ]
Sotnikova, TD [1 ]
Grekhova, TV [1 ]
Rayevsky, KS [1 ]
机构
[1] Russian Acad Med Sci, Inst Pharmacol, Lab Neurochem Pharmacol, Moscow 125315, Russia
关键词
dopamine release; microdialysis; psychostimulant drug; Sydnocarb;
D O I
10.1016/S0014-2999(97)01407-6
中图分类号
R9 [药学];
学科分类号
1007 ;
摘要
Transcerebral microdialysis was used to evaluate the effect of a psychostimulant drug, sydnocarb (3-(beta-phenylisopropyl)-N-phenylcarbamoylsydnonimine), on the extracellular levels of dopamine, 3,4-dihydroxyphenylacetic acid (DOPAC) and homovanillic acid (HVA) in the dorsal striatum and nucleus accumbens of freely moving rats. Sydnocarb dose dependently (4.4, 8.75 and 17.5 mg/kg, i.p.) induced a relatively modest (up to 350% of control) and long-lasting (up to 6 h) increase in dopamine extracellular level in the rat dorsal striatum. The drug at 8.75 mg/kg, i.p., produced an approximately similar increase in dopamine efflux in the dorsal striatum and in the nucleus accumbens of freely moving rats. Sydnocarb had no effect on DOPAC or HVA extracellular levels in the rat basal ganglia in vivo at any dose studied. It is important that the drug increased the efflux of dopamine in a tetrodotoxin-sensitive and Ca2+-dependent manner. Measurements of behavioral parameters in non-operated rats revealed that sydnocarb markedly increased locomotor activity and induced stereotyped behavior. These data suggest that the stimulant action of sydnocarb is accompanied by a facilitation of central dopaminergic transmission involving an increase in Ca2+-dependent vesicular dopamine efflux. (C) 1997 Published by Elsevier Science B.V.
引用
收藏
页码:53 / 58
页数:6
相关论文
共 25 条
  • [1] ALTSHULE.RA, 1973, FARMAKOL TOKSIKOL, V36, P18
  • [2] AVRUTSKY GY, 1988, TREATMENT PSYCHIAT P
  • [3] CHARACTERIZATION OF METHYLPHENIDATE AND NOMIFENSINE INDUCED DOPAMINE RELEASE IN RAT STRIATUM USING INVIVO BRAIN MICRODIALYSIS
    BUTCHER, SP
    LIPTROT, J
    ABURTHNOTT, GW
    [J]. NEUROSCIENCE LETTERS, 1991, 122 (02) : 245 - 248
  • [4] AMPHETAMINE-INDUCED DOPAMINE RELEASE IN THE RAT STRIATUM - AN INVIVO MICRODIALYSIS STUDY
    BUTCHER, SP
    FAIRBROTHER, IS
    KELLY, JS
    ARBUTHNOTT, GW
    [J]. JOURNAL OF NEUROCHEMISTRY, 1988, 50 (02) : 346 - 355
  • [5] AMPHETAMINE, COCAINE, PHENCYCLIDINE AND NOMIFENSINE INCREASE EXTRACELLULAR DOPAMINE CONCENTRATIONS PREFERENTIALLY IN THE NUCLEUS ACCUMBENS OF FREELY MOVING RATS
    CARBONI, E
    IMPERATO, A
    PEREZZANI, L
    DICHIARA, G
    [J]. NEUROSCIENCE, 1989, 28 (03) : 653 - 661
  • [6] DICHIARA G, 1988, P NATL ACAD SCI USA, V85, P5274
  • [7] ERDO SL, 1981, POL J PHARMACOL PHAR, V33, P141
  • [8] DOPAMINE D-2 AND D-3 RECEPTOR PREFERRING ANTAGONISTS DIFFERENTIALLY AFFECT STRIATAL DOPAMINE RELEASE AND METABOLISM IN CONSCIOUS RATS
    GAINETDINOV, RR
    GREKHOVA, TV
    SOTNIKOVA, TD
    RAYEVSKY, KS
    [J]. EUROPEAN JOURNAL OF PHARMACOLOGY, 1994, 261 (03) : 327 - 331
  • [9] INVIVO NEUROCHEMICAL PROFILE OF DOPAMINE UPTAKE INHIBITORS AND RELEASERS IN RAT CAUDATE-PUTAMEN
    HURD, YL
    UNGERSTEDT, U
    [J]. EUROPEAN JOURNAL OF PHARMACOLOGY, 1989, 166 (02) : 251 - 260
  • [10] AMPEROZIDE, A NOVEL ANTIPSYCHOTIC DRUG, INHIBITS THE ABILITY OF D-AMPHETAMINE TO INCREASE DOPAMINE RELEASE INVIVO IN RAT STRIATUM AND NUCLEUS-ACCUMBENS
    ICHIKAWA, J
    MELTZER, HY
    [J]. JOURNAL OF NEUROCHEMISTRY, 1992, 58 (06) : 2285 - 2291