Effects of a psychostimulant drug Sydnocarb on rat brain dopaminergic transmission in vivo

被引:14
作者
Gainetdinov, RR [1 ]
Sotnikova, TD [1 ]
Grekhova, TV [1 ]
Rayevsky, KS [1 ]
机构
[1] Russian Acad Med Sci, Inst Pharmacol, Lab Neurochem Pharmacol, Moscow 125315, Russia
关键词
dopamine release; microdialysis; psychostimulant drug; Sydnocarb;
D O I
10.1016/S0014-2999(97)01407-6
中图分类号
R9 [药学];
学科分类号
1007 ;
摘要
Transcerebral microdialysis was used to evaluate the effect of a psychostimulant drug, sydnocarb (3-(beta-phenylisopropyl)-N-phenylcarbamoylsydnonimine), on the extracellular levels of dopamine, 3,4-dihydroxyphenylacetic acid (DOPAC) and homovanillic acid (HVA) in the dorsal striatum and nucleus accumbens of freely moving rats. Sydnocarb dose dependently (4.4, 8.75 and 17.5 mg/kg, i.p.) induced a relatively modest (up to 350% of control) and long-lasting (up to 6 h) increase in dopamine extracellular level in the rat dorsal striatum. The drug at 8.75 mg/kg, i.p., produced an approximately similar increase in dopamine efflux in the dorsal striatum and in the nucleus accumbens of freely moving rats. Sydnocarb had no effect on DOPAC or HVA extracellular levels in the rat basal ganglia in vivo at any dose studied. It is important that the drug increased the efflux of dopamine in a tetrodotoxin-sensitive and Ca2+-dependent manner. Measurements of behavioral parameters in non-operated rats revealed that sydnocarb markedly increased locomotor activity and induced stereotyped behavior. These data suggest that the stimulant action of sydnocarb is accompanied by a facilitation of central dopaminergic transmission involving an increase in Ca2+-dependent vesicular dopamine efflux. (C) 1997 Published by Elsevier Science B.V.
引用
收藏
页码:53 / 58
页数:6
相关论文
共 25 条
  • [11] THE INTERACTION OF CLOZAPINE WITH DOPAMINE D1 VERSUS DOPAMINE D2 RECEPTOR-MEDIATED FUNCTION - BEHAVIORAL INDEXES
    MURRAY, AM
    WADDINGTON, JL
    [J]. EUROPEAN JOURNAL OF PHARMACOLOGY, 1990, 186 (01) : 79 - 86
  • [12] INVIVO CHARACTERIZATION OF LOCALLY APPLIED DOPAMINE UPTAKE INHIBITORS BY STRIATAL MICRODIALYSIS
    NOMIKOS, GG
    DAMSMA, G
    WENKSTERN, D
    FIBIGER, HC
    [J]. SYNAPSE, 1990, 6 (01) : 106 - 112
  • [13] CHRONIC DESIPRAMINE ENHANCES AMPHETAMINE-INDUCED INCREASES IN INTERSTITIAL CONCENTRATIONS OF DOPAMINE IN THE NUCLEUS-ACCUMBENS
    NOMIKOS, GG
    DAMSMA, G
    WENKSTERN, D
    FIBIGER, HC
    [J]. EUROPEAN JOURNAL OF PHARMACOLOGY, 1991, 195 (01) : 63 - 73
  • [14] ACUTE EFFECTS OF BUPROPION ON EXTRACELLULAR DOPAMINE CONCENTRATIONS IN RAT STRIATUM AND NUCLEUS ACCUMBENS STUDIED BY INVIVO MICRODIALYSIS
    NOMIKOS, GG
    DAMSMA, G
    WENKSTERN, D
    FIBIGER, HC
    [J]. NEUROPSYCHOPHARMACOLOGY, 1989, 2 (04) : 273 - 279
  • [15] Paxinos G., 1997, RAT BRAIN STEROTAXIC, VThird
  • [16] RAYEVSKY KS, 1995, PHARMACOL RES S, V31, P30
  • [17] ROBINSON TE, 1990, NEUROPSYCHOPHARMACOL, V3, P163
  • [18] CENTRAL STIMULATORY ACTION OF INHIBITORS OF THE DOPAMINE UPTAKE
    ROSS, SB
    [J]. LIFE SCIENCES, 1979, 24 (02) : 159 - 167
  • [19] RUDENKO GM, 1979, AGRESSOLOGIE, V20, P265
  • [20] A DIRECT COMPARISON OF AMPHETAMINE-INDUCED BEHAVIORS AND REGIONAL BRAIN DOPAMINE RELEASE IN THE RAT USING INTRACEREBRAL DIALYSIS
    SHARP, T
    ZETTERSTROM, T
    LJUNGBERG, T
    UNGERSTEDT, U
    [J]. BRAIN RESEARCH, 1987, 401 (02) : 322 - 330