Drosophila melanogaster Thor and response to Candida albicans infection

被引：19

作者：

Levitin, A.

Marcil, A.

Tettweiler, G.

Laforest, M. J.

Oberholzer, U.

Alarco, A. M.

Thomas, D. Y.

Lasko, P.

Whiteway, M.

机构：

[1] Natl Res Council Canada, Biotechnol Res Inst, Genet Grp, Montreal, PQ H4P 2R2, Canada

[2] McGill Univ, Dept Biol, Montreal, PQ H3A 1B1, Canada

[3] McGill Univ, Dept Biochem, Montreal, PQ H3G 1Y6, Canada

来源：

EUKARYOTIC CELL | 2007年 / 6卷 / 04期

关键词：

D O I：

10.1128/EC.00346-06

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

We used Drosophila melanogaster macrophage-like Schneider 2 (S2) cells as a model to study cell-mediated innate immunity against infection by the opportunistic fungal pathogen Candida albicans. Transcriptional profiling of S2 cells coincubated with C. albicans cells revealed up-regulation of several genes. One of the most highly up-regulated genes during this interaction is the D. melanogaster translational regulator 4E-BP encoded by the Thor gene. Analysis of Drosophila 4E-BPnull mutant survival upon infection with C. albicans showed that 4E-BP plays an important role in host defense, suggesting a role for translational control in the D. melanogaster response to C. albicans infection.

引用

页码：658 / 663

页数：6

共 34 条

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