ATP as a signaling molecule: The exocrine focus

被引:143
作者
Novak, I [1 ]
机构
[1] Univ Copenhagen, August Krogh Inst, DK-2100 Copenhagen, Denmark
来源
NEWS IN PHYSIOLOGICAL SCIENCES | 2003年 / 18卷
关键词
D O I
10.1152/nips.01409.2002
中图分类号
Q4 [生理学];
学科分类号
071003 ;
摘要
Why and how do cells release ATP? It is not spilled energy. A TP becomes an extracellular regulator. Various cellular responses are initiated by purinergic receptors and signaling processes and are terminated by breakdown of ATP by ectonucleotidases. In epithelia, ATP regulates salt and water transport; other effects may be longer lasting.
引用
收藏
页码:12 / 17
页数:6
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共 20 条
[1]   Bromoenol lactone enhances the permeabilization of rat submandibular acinar cells by P2X7 agonists [J].
Chaïb, N ;
Kabré, E ;
Alzola, E ;
Pochet, S ;
Dehaye, JP .
BRITISH JOURNAL OF PHARMACOLOGY, 2000, 129 (04) :703-708
[2]  
Cotrina ML, 2000, J NEUROSCI, V20, P2835
[3]   Purinoceptors evoke different electrophysiological responses in pancreatic ducts -: P2Y inhibits K+ conductance, and P2X stimulates cation conductance [J].
Hede, SE ;
Amstrup, J ;
Christoffersen, BC ;
Novak, I .
JOURNAL OF BIOLOGICAL CHEMISTRY, 1999, 274 (45) :31784-31791
[4]   Transporters of nucleotide sugars, ATP, and nucleotide sulfate in the endoplasmic reticulum and Golgi apparatus [J].
Hirschberg, CB ;
Robbins, PW ;
Abeijon, C .
ANNUAL REVIEW OF BIOCHEMISTRY, 1998, 67 :49-69
[5]   Effect of luminal nucleotides on Cl- secretion and Na+ absorption in distal bronchi [J].
Inglis, SK ;
Collett, A ;
McAlroy, HL ;
Wilson, SM ;
Olver, RE .
PFLUGERS ARCHIV-EUROPEAN JOURNAL OF PHYSIOLOGY, 1999, 438 (05) :621-627
[6]   Luminal ATP stimulates fluid and HCO3- secretion in guinea-pig pancreatic duct [J].
Ishiguro, H ;
Naruse, X ;
Kitagawa, M ;
Hayakawa, T ;
Case, RM ;
Steward, MC .
JOURNAL OF PHYSIOLOGY-LONDON, 1999, 519 (02) :551-558
[7]  
Khakh BS, 2001, PHARMACOL REV, V53, P107
[8]   Proteomic and functional evidence for a P2X7 receptor signalling complex [J].
Kim, M ;
Jiang, LH ;
Wilson, HL ;
North, RA ;
Surprenant, A .
EMBO JOURNAL, 2001, 20 (22) :6347-6358
[9]   Characterization and localization of P2 receptors in rat submandibular gland acinar and duct cells [J].
Lee, MG ;
Zeng, WZ ;
Muallem, S .
JOURNAL OF BIOLOGICAL CHEMISTRY, 1997, 272 (52) :32951-32955
[10]   Brefeldin a block of integrin-dependent mechanosensitive ATP release from Xenopus oocytes reveals a novel mechanism of mechanotransduction [J].
Maroto, R ;
Hamill, OP .
JOURNAL OF BIOLOGICAL CHEMISTRY, 2001, 276 (26) :23867-23872