ATP as a signaling molecule: The exocrine focus

被引：143

作者：

Novak, I ^{[1
]}

机构：

[1] Univ Copenhagen, August Krogh Inst, DK-2100 Copenhagen, Denmark

来源：

NEWS IN PHYSIOLOGICAL SCIENCES | 2003年 / 18卷

关键词：

D O I：

10.1152/nips.01409.2002

中图分类号：

Q4 [生理学];

学科分类号：

071003 ;

摘要：

Why and how do cells release ATP? It is not spilled energy. A TP becomes an extracellular regulator. Various cellular responses are initiated by purinergic receptors and signaling processes and are terminated by breakdown of ATP by ectonucleotidases. In epithelia, ATP regulates salt and water transport; other effects may be longer lasting.

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页码：12 / 17

页数：6

相关论文

共 20 条

[11] PROPERTIES OF THE LUMINAL MEMBRANE OF ISOLATED PERFUSED RAT PANCREATIC DUCTS - EFFECT OF CYCLIC-AMP AND BLOCKERS OF CHLORIDE TRANSPORT [J].

NOVAK, I ;

GREGER, R .

PFLUGERS ARCHIV-EUROPEAN JOURNAL OF PHYSIOLOGY, 1988, 411 (05) :546-553

[12] Purinergic receptors have different effects in rat exocrine pancreas. calcium signals monitored by Fura-2 using confocal microscopy [J].

Novak, I ;

Nitschke, R ;

Amstrup, J .

CELLULAR PHYSIOLOGY AND BIOCHEMISTRY, 2002, 12 (2-3) :83-92

[13] Polarized signaling via purinoceptors in normal and cystic fibrosis airway epithelia [J].

Paradiso, AM ;

Ribeiro, CMP ;

Boucher, RC .

JOURNAL OF GENERAL PHYSIOLOGY, 2001, 117 (01) :53-67

[14]

Ralevic V, 1998, PHARMACOL REV, V50, P413

[15] Extracellular nucleotide signaling along the renal epithelium [J].

Schwiebert, EM ;

Kishore, BK .

AMERICAN JOURNAL OF PHYSIOLOGY-RENAL PHYSIOLOGY, 2001, 280 (06) :F945-F963

[16] EFFECTS OF EXTRACELLULAR ATP ON ION-TRANSPORT SYSTEMS AND [CA-2+]I IN RAT PAROTID ACINAR-CELLS - COMPARISON WITH THE MUSCARINIC AGONIST CARBACHOL [J].

SOLTOFF, SP ;

MCMILLIAN, MK ;

CRAGOE, EJ ;

CANTLEY, LC ;

TALAMO, BR .

JOURNAL OF GENERAL PHYSIOLOGY, 1990, 95 (02) :319-346

[17] Visualization of ATP release in pancreatic acini in response to cholinergic stimulus - Use of fluorescent probes and confocal microscopy [J].

Sorensen, CE ;

Novak, I .

JOURNAL OF BIOLOGICAL CHEMISTRY, 2001, 276 (35) :32925-32932

[18] Expression and trans-synaptic regulation of P2x4 and P2z receptors for extracellular ATP in parotid acinar cells -: Effects of parasympathetic denervation [J].

Tenneti, L ;

Gibbons, SJ ;

Talamo, BR .

JOURNAL OF BIOLOGICAL CHEMISTRY, 1998, 273 (41) :26799-26808

[19] Extracellular metabolism of ATP and other nucleotides [J].

Zimmermann, H .

NAUNYN-SCHMIEDEBERGS ARCHIVES OF PHARMACOLOGY, 2000, 362 (4-5) :299-309

[20] Ca2+-activated Cl- channels can substitute for CFTR in stimulation of pancreatic duct bicarbonate secretion [J].

Zsembery, A ;

Strazzabosco, M ;

Graf, J .

FASEB JOURNAL, 2000, 14 (14) :2345-2356