Electrokinetic focusing injection methods on microfluidic devices

被引：86

作者：

Fu, LM ^{[1
]}

Yang, RJ ^{[1
]}

Lee, GB ^{[1
]}

机构：

[1] Natl Cheng Kung Univ, Dept Engn Sci, Tainan 70101, Taiwan

来源：

ANALYTICAL CHEMISTRY | 2003年 / 75卷 / 08期

关键词：

D O I：

10.1021/ac020741d

中图分类号：

O65 [分析化学];

学科分类号：

070302 ; 081704 ;

摘要：

This paper presents an experimental and numerical investigation into electrokinetic focusing injection on microfluidic chips. The valving characteristics on microfluidic devices are controlled through appropriate manipulations of the electric potential strengths during the sample loading and dispensing steps. The present study also addresses the design and testing of various injection systems used to deliver a sample plug. A novel double-cross injection microfluidic chip is fabricated, which employs electrokinetic focusing to deliver sample plugs of variable volume. The proposed design combines several functions of traditional sample plug injection systems on a single microfluidic chip. The injection technique uses an unique sequence of loading steps with different electric potential distributions and magnitudes within the various channels to effectuate a virtual valve.

引用

页码：1905 / 1910

页数：6