The enantioselective morita-baylis-hiliman reaction and its aza counterpart

被引：488

作者：

Masson, Geraldine ^{[1
]}

Housseman, Christopher ^{[1
]}

Zhu, Jieping ^{[1
]}

机构：

[1] CNRS, Inst Chim Subst Nat, F-91198 Gif Sur Yvette, France

来源：

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION | 2007年 / 46卷 / 25期

关键词：

asymmetric synthesis; Bronsted acids; Lewis bases; organocatalysis; reaction mechanisms;

D O I：

10.1002/anie.200604366

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

The development of asymmetric Morita-Baylis-Hillman (MBH) reactions has evolved dramatically over the past few years, parallel to the emerging concept of bifunctional organocatalysis. Whereas organocatalysis is starting to compete with metal-based catalysis in several important organic transformations, the MBH reaction belongs to a group of prototypical reactions in which organocatalysis already display superiority over their metal-based counterparts. This Minireview summarizes recent mechanistic insights and advances in the design and synthesis of small organic molecules for enantioselective MBH and aza-MBH reactions. © 2007 Wiley-VCH Verlag GmbH & Co. KGaA.

引用

页码：4614 / 4628

页数：15

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