SYNPHOS:: A new atropisomeric diphosphine ligand.: From laboratory-scale synthesis to scale-up development

被引：71

作者：

de Paule, SD

Jeulin, S

Ratovelomanana-Vidal, V

Genêt, JP

Champion, N

Deschaux, G

Dellis, P

机构：

[1] ENSCP, Lab Synthese Select Organ & Prod Nat, F-75231 Paris 05, France

[2] SYNKEM SAS, F-21301 Chenove, France

来源：

ORGANIC PROCESS RESEARCH & DEVELOPMENT | 2003年 / 7卷 / 03期

关键词：

D O I：

10.1021/op034016w

中图分类号：

O69 [应用化学];

学科分类号：

081704 ;

摘要：

A new optically active diphosphine ligand, [(5,6),(5',6')-bis(ethlenedioxy)biphenyl-2,2'-diyl]bis(diphenylphosphine) (SYNPHOS) has been synthesized. Laboratory-scale synthesis and scale-up development of this ligand are described herein. This new atropisomeric diphosphine was also used in ruthenium-catalyzed asymmetric hydrogenation.

引用

页码：399 / 406

页数：8

共 31 条

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