Asymmetric synthesis of fluorinated β-hydroxy esters via ruthenium-mediated hydrogenation

被引：32

作者：

Blanc, D

Ratovelomanana-Vidal, V

Gillet, JP

Genêt, JP

机构：

[1] Ecole Natl Sup Chim Paris, Lab Synthese Select Organ Prod Nat, CNRS UMR 7573, F-75231 Paris 05, France

[2] Elf Atochem, Ctr Rech Rhone Alpes, F-69493 Pierre Benite, France

来源：

JOURNAL OF ORGANOMETALLIC CHEMISTRY | 2000年 / 603卷 / 01期

关键词：

ruthenium catalysts; chiral hydrogenation; fluoroorganic compounds;

D O I：

10.1016/S0022-328X(00)00174-1

中图分类号：

O61 [无机化学];

学科分类号：

070301 ; 081704 ;

摘要：

The homogeneous asymmetric hydrogenation reactions of fluorinated P-keto esters using ruthenium(II) complexes bearing atropoisomeric diphosphines such as BINAP and MeO-BIPHEP have yielded the corresponding P-hydroxy esters in quantitative yield with ee that ranged between 42 and > 95%. (C) 2000 Published by Elsevier Science S.A. All rights reserved.

引用

页码：128 / 130

页数：3

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