Notch2 is preferentially expressed in mature B cells and indispensable for marginal zone B lineage development

被引：446

作者：

Saito, T

Chiba, S

Ichikawa, M

Kunisato, A

Asai, T

Shimizu, K

Yamaguchi, T

Yamamoto, G

Seo, S

Kumano, K

Nakagami-Yamaguchi, E

Hamada, Y

Aizawa, S

Hirai, H

机构：

[1] Univ Tokyo, Grad Sch Med, Dept Hematol & Oncol, Bunkyo Ku, Tokyo 1138655, Japan

[2] Univ Tokyo, Grad Sch Med, Dept Cell Therapy & Transplantat Med, Bunkyo Ku, Tokyo 1138655, Japan

[3] Univ Tokyo, Grad Sch Med, Dept Blood Transfus Med, Bunkyo Ku, Tokyo 1138655, Japan

[4] Natl Inst Basic Biol, Tissue & Cell Culture Lab, Okazaki, Aichi 4448585, Japan

[5] RIKEN, Ctr Dev Biol, Lab Vertebrate Body Plan, Chuo Ku, Kobe, Hyogo 6500047, Japan

来源：

IMMUNITY | 2003年 / 18卷 / 05期

关键词：

D O I：

10.1016/S1074-7613(03)00111-0

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

The Notch genes play a key role in cellular differentiation. The significance of Notch1 during thymocyte development is well characterized, but the function of Notch2 is poorly understood. Here we demonstrate that Notch2 but no other Notch family member is preferentially expressed in mature B cells and that conditionally targeted deletion of Notch2 results in the defect of marginal zone B (MZB) cells and their presumed precursors, CD1d(hi) fraction of type 2 transitional B cells. Among Notch target genes, the expression level of Deltex1 is prominent in MZB cells and strictly dependent on that of Notch2, suggesting that Deltex1 may play a role in MZB cell differentiation.

引用

页码：675 / 685

页数：11

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