Recent advances in aldolase-catalyzed asymmetric synthesis

被引：181

作者：

Dean, Stephen M. ^{[1
]}

Greenberg, William A. ^{[1
]}

Wong, Chi-Huey ^{[1
]}

机构：

[1] Scripps Res Inst, Dept Chem, La Jolla, CA 92037 USA

来源：

ADVANCED SYNTHESIS & CATALYSIS | 2007年 / 349卷 / 8-9期

关键词：

aldol reaction; asymmetric catalysis; directed evolution; enzyme catalysis;

D O I：

10.1002/adsc.200700115

中图分类号：

O69 [应用化学];

学科分类号：

081704 ;

摘要：

This review is focused on advances over the last several years in the application of aldolases to organic synthesis. Several new technologies have been implemented to increase the scope and practicality of aldolases as tools for the synthetic chemist. These include directed evolution, discovery of new classes of aldolases in nature and the laboratory, and substrate and reaction engineering. 1 Introduction 2 Directed Evolution and Enzyme Engineering 2.1 DHAP-Dependent Aldolases 2.2 Pyruvate-Dependent Aldolases 2.3 Acetaldehyde-Dependent Aldoases 3, Discovery of Novel Aldolases 4 Reaction and Substrate Engineering 5 Future Prospects and Challenges

引用

页码：1308 / 1320

页数：13

共 60 条

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