Prominent sensory ataxia in Guillain-Barre syndrome associated with IgG anti-GD1b antibody

被引：29

作者：

Wicklein, EM ^{[1
]}

Pfeiffer, G ^{[1
]}

Yuki, N ^{[1
]}

Hartard, C ^{[1
]}

Kunze, K ^{[1
]}

机构：

[1] DOKKYO UNIV,SCH MED,DEPT NEUROL,MIBU,TOCHIGI 32102,JAPAN

来源：

JOURNAL OF THE NEUROLOGICAL SCIENCES | 1997年 / 151卷 / 02期

关键词：

Guillain-Barre syndrome; acute sensory neuropathy; anti-ganglioside antibody; anti-GD1b antibody;

D O I：

10.1016/S0022-510X(97)00136-6

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

Sensitization with GD1b has been shown to cause sensory neuropathy in rabbit. A patient with chronic sensory-dominant polyneuropathy who had IgM antibody specifically to GD1b has been reported previously. This report describes the first patient with acute demyelinating polyneuropathy with prominent sensory symptoms who had a high titer of serum IgG anti-GD1b antibody. The serum reacted with neither GM1 nor with other b-series gangliosides (GD2, GD3, GT1b and GQ1b). Improvement in symptoms was coincident with decrease in IgG anti-GD1b antibody titer after plasmapheresis. This case supports the experimental results in rabbit suggesting that anti-GD1b antibody functions in the development of sensory ataxia. (C) 1997 Elsevier Science B.V.

引用

页码：227 / 229

页数：3

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