ACUTE ATAXIC NEUROPATHY WITH CROSS-REACTIVE ANTIBODIES TO GD(1B) AND GD(3) GANGLIOSIDES

被引：54

作者：

WILLISON, HJ ^{[1
]}

ALMEMAR, A ^{[1
]}

VEITCH, J ^{[1
]}

THRUSH, D ^{[1
]}

机构：

[1] DERRIFORD HOSP,DEPT NEUROL,PLYMOUTH,DEVON,ENGLAND

来源：

NEUROLOGY | 1994年 / 44卷 / 12期

关键词：

D O I：

10.1212/WNL.44.12.2395

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

We report a patient with an acute, self-limiting neuropathy consisting of ataxia and areflexia, but without ophthalmoplegia or limb weakness, with transient, high-titer serum IgG antibodies to a single NeuAc(alpha 2-8)NeuAc-linked disialosyl epitope, as found on GD(1b) and GD(3) gangliosides. The serum did not react with GQ(1b), GT(1a), or GT(1b). This atypical case, which most closely represents an incomplete Miller Fisher syndrome, indicates that anti-GD(1b)/GD(3) antibodies may be able to induce sensory ataxia.

引用

页码：2395 / 2397

页数：3

共 10 条

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