Increased cortical inhibition induced by apomorphine in patients with Parkinson's disease

被引：15

作者：

Manfredi, L ^{[1
]}

Garavaglia, P ^{[1
]}

Beretta, S ^{[1
]}

Pellegrini, G ^{[1
]}

机构：

[1] Osped Valduce, Dept Neurol, I-22100 Como, Italy

来源：

NEUROPHYSIOLOGIE CLINIQUE-CLINICAL NEUROPHYSIOLOGY | 1998年 / 28卷 / 01期

关键词：

Parkinson's disease; transcranial stimulation; cortical stimulation; silent period; multiple system atrophy;

D O I：

10.1016/S0987-7053(97)89576-7

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

The electromyographic silent period following the motor potential evoked by cortical magnetic stimulation is decreased in parkinsonian patients. In this study we investigated whether the decrease in the silent period is connected only with parkinsonian symptoms. We evaluated the effect of apomorphine (a potent and rapid dopamine-agonist) on the changes in the peripheral and central silent period in 29 patients with Parkinson's disease and in two patients affected by multisystem atrophy (MSA). Apomorphine injection was found to induce a significant improvement in the central silent period in parkinsonian patients but not in the MSA patients, suggesting a relation between the clinical parkinsonian symptoms (akinesia and rigidity) and the silent period duration. The central silent period changes after apomorphine injection could be used as an adjunctive, safe and effective diagnostic tool to assess dopamine responsiveness of parkinsonian syndromes. (C) 1998 Elsevier, Paris.

引用

页码：31 / 38

页数：8

共 27 条

[11] LATENCY AND DURATION OF THE MUSCLE SILENT PERIOD FOLLOWING TRANSCRANIAL MAGNETIC STIMULATION IN MULTIPLE-SCLEROSIS, CEREBRAL-ISCHEMIA, AND OTHER UPPER MOTONEURON LESIONS
HAUG, BA
KUKOWSKI, B
[J]. NEUROLOGY, 1994, 44 (05) : 936 - 940
[12] HIGGINS DC, 1971, J NEUROL NEUROSUR PS, V43, P508
[13] PARKINSONISM - ONSET PROGRESSION AND MORTALITY
HOEHN, MM
YAHR, MD
[J]. NEUROLOGY, 1967, 17 (05) : 427 - &
[14] INGHILLIERI M, 1993, J PHYSIOL-LONDON, V446, P521
[15] THE SILENT PERIOD IN A MUSCLE OF THE HUMAN HAND
MERTON, PA
[J]. JOURNAL OF PHYSIOLOGY-LONDON, 1951, 114 (1-2): : 183 - 198
[16] NAKASHIMA K, 1992, Electromyography and Clinical Neurophysiology, V32, P215
[17] Computer-aided determination of the silent period
Nilsson, J
Panizza, M
Arieti, P
[J]. JOURNAL OF CLINICAL NEUROPHYSIOLOGY, 1997, 14 (02) : 136 - 143
[18] MOTOR CORTICAL INHIBITION AND THE DOPAMINERGIC SYSTEM - PHARMACOLOGICAL CHANGES IN THE SILENT PERIOD AFTER TRANSCRANIAL BRAIN-STIMULATION IN NORMAL SUBJECTS, PATIENTS WITH PARKINSONS-DISEASE AND DRUG-INDUCED PARKINSONISM
PRIORI, A
BERARDELLI, A
INGHILLERI, M
ACCORNERO, N
MANFREDI, M
[J]. BRAIN, 1994, 117 : 317 - 323
[19] THE CORTICAL SILENT PERIOD AND AMYOTROPHIC-LATERAL-SCLEROSIS
PROUT, AJ
EISEN, AA
[J]. MUSCLE & NERVE, 1994, 17 (02) : 217 - 223
[20] PERIPHERAL AND CENTRAL PHARMACOKINETICS OF APOMORPHINE AND ITS EFFECT ON DOPAMINE METABOLISM IN HUMANS
PRZEDBORSKI, S
LEVIVIER, M
RAFTOPOULOS, C
NAINI, AB
HILDEBRAND, J
[J]. MOVEMENT DISORDERS, 1995, 10 (01) : 28 - 36

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