Correlation between a phenotypic assay and three bioinformatic tools for determining HIV co-receptor use

被引：41

作者：

Poveda, Eva ^{[1
]}

Briz, Verónica

Roulet, Vanessa

Gonzalez, Maria del Mar

Faudon, Jean-Louis

Skrabal, Katharina

Soriano, Vincent

机构：

[1] Hosp Carlos III, Dept Infect Dis, Madrid, Spain

[2] Eurofins Viralliance, Kalamazoo, MI USA

[3] Bioalliance Pharma, Paris, France

来源：

AIDS | 2007年 / 21卷 / 11期

关键词：

V3; LOOP; ENTRY; TROPISM; IDENTIFICATION; INHIBITORS; V2;

D O I：

10.1097/QAD.0b013e32826fb741

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

The predictive value of three genotypic methods to determine HIV-1 co-recepitor usage was assessed in 83 plasma specimens taking as reference the results obtained using a recombinant phenotypic assay (Phenoscript). The best concordance was found for webPSSM, followed by geno2pheno and wetcat (85.9, 71.8 and 70.5%, respectively). Less than 5.1% of phenotypic X4 viruses were missed by genotypic tools. The genotypic prediction of HIV-1 co-receptor usage can thus assist therapeutic decisions for using CCR5 antagonists.

引用

页码：1487 / 1490

页数：4

共 21 条

[11] Improved coreceptor usage prediction and genotypic monitoring of R5-to-X4 transition by motif analysis of human immunodeficiency virus type 1 env V3 loop sequences [J].