A Tumor-Acidity-Activated Charge-Conversional Nanogel as an Intelligent Vehicle for Promoted Tumoral-Cell Uptake and Drug Delivery

被引：484

作者：

Du, Jin-Zhi ^{[1
,2
]}

Sun, Tian-Meng ^{[3
,4
]}

Song, Wen-Jing ^{[3
,4
]}

Wu, Juan ^{[1
,2
]}

Wang, Jun ^{[3
,4
]}

机构：

[1] Univ Sci & Technol China, Dept Polymer Sci & Engn, Hefei 230026, Anhui, Peoples R China

[2] Univ Sci & Technol China, CAS Key Lab Soft Matter Chem, Hefei 230026, Anhui, Peoples R China

[3] Univ Sci & Technol China, Hefei Natl Lab Phys Sci Microscale, Hefei 230027, Anhui, Peoples R China

[4] Univ Sci & Technol China, Sch Life Sci, Hefei 230027, Anhui, Peoples R China

来源：

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION | 2010年 / 49卷 / 21期

基金：

中国国家自然科学基金;

关键词：

antitumor agents; charge conversion; drug delivery; nanoparticles; pH-responsive; MULTIFUNCTIONAL POLYMERIC MICELLE; GENE DELIVERY; MULTIDRUG-RESISTANCE; ENDOSOMAL PH; DOXORUBICIN; CANCER; NANOPARTICLES; NANOCARRIERS; INTERNALIZATION; PARTICLES;

D O I：

10.1002/anie.200907210

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

(Figure Presented) A positive (or negative) chameleon : A nanogel that is negatively charged at physiological pH values and activated to be positively charged at tumor extracellular pH values was internalized efficiently by tumor cells both in vitro and in vivo (see illustration). Intracellular drug release was also enhanced, probably as a result of a decrease in the interaction between the drug and the nanogel in its protonated state. © 2010 Wiley-VCH Verlag GmbH & Co. KCaA.

引用

页码：3621 / 3626

页数：6

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