Novel antifungal polyene amides from the myxobacterium Cystobacter fuscus:: isolation, antifungal activity and absolute structure determination

被引：20

作者：

Kundim, BA

Itou, Y

Sakagami, Y

Fudou, R

Yamanaka, S

Ojika, M ^{[1
]}

机构：

[1] Nagoya Univ, Grad Sch Bioagr Sci, Chikusa Ku, Nagoya, Aichi 4648601, Japan

[2] Ajinomoto Co Inc, Inst Life Sci, Kawasaki Ku, Kawasaki, Kanagawa 2100801, Japan

[3] Shinshu Univ, Fac Text Sci & Technol, Ueda, Nagano 3868567, Japan

来源：

TETRAHEDRON | 2004年 / 60卷 / 45期

基金：

日本学术振兴会;

关键词：

myxobacteria; Cystobacter fuscus; antifungal; polyene antibiotics;

D O I：

10.1016/j.tet.2004.09.013

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Three new unstable metabolites, (6E,10Z)-2'-O-methylmyxalamide D (1), 2'-O-methylmyxalamide D (2) and (6E)-2'-O-methylmyxalamide D (3) were isolated from the myxobacterium Cystobacter fuscus. The planar structures were elucidated by spectroscopic analyses to be geometrical isomers of a polyene amide related to a myxobacterial metabolite, myxalamide D (4). Their absolute stereochemistry was determined by synthesis of degradation products. Antifungal activities of 1-3 as well as their acetates were evaluated against the phythopathogenic fungus Phythopthora capsici. (C) 2004 Elsevier Ltd. All rights reserved.

引用

页码：10217 / 10221

页数：5

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