Histone H1: Lessons from Drosophila

被引：17

作者：

Bayona-Feliu, Aleix ^{[1
,2
]}

Casas-Lamesa, Anna ^{[1
,2
]}

Carbonell, Albert ^{[1
,2
]}

Climent-Canto, Paula ^{[1
,2
]}

Tatarski, Milos ^{[1
,2
]}

Perez-Montero, Salvador ^{[1
,2
]}

Azorin, Fernando ^{[1
,2
]}

Bernues, Jordi ^{[1
,2
]}

机构：

[1] CSIC, Inst Mol Biol Barcelona IBMB, Parc Cient Barcelona,Baldiri Reixac 4, E-08028 Barcelona, Spain

[2] Inst Res Biomed Barcelona, Parc Cient Barcelona,Baldiri Reixac 10, Barcelona 08028, Spain

来源：

BIOCHIMICA ET BIOPHYSICA ACTA-GENE REGULATORY MECHANISMS | 2016年 / 1859卷 / 03期

关键词：

CEREVISIAE LINKER HISTONE; IN-VIVO; SACCHAROMYCES-CEREVISIAE; CHROMATIN-STRUCTURE; POSTTRANSLATIONAL MODIFICATIONS; GENE-EXPRESSION; CORE PARTICLE; NUCLEOSOME; PHOSPHORYLATION; MELANOGASTER;

D O I：

10.1016/j.bbagrm.2015.09.001

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

070307 [化学生物学]; 071010 [生物化学与分子生物学];

摘要：

Eukaryotic genomes are structured in the form of chromatin with the help of a set of five small basic proteins, the histones. Four of them are highly conserved through evolution, form the basic unit of the chromatin, the nucleosome, and have been intensively studied and are well characterized. The fifth histone, histone H1, adds to this basic structure through its interaction at the entry/exit site of DNA in the nucleosome and makes an essential contribution to the higher order folding of the chromatin fiber. Histone H1 is the less conserved histone and the less known of them. Though for long time considered as a general repressor of gene expression, recent studies in Drosophila have rejected this view and have contributed to uncover important functions on genome stability and development. Here we present some of the most recent data obtained in the Drosophila model system and discuss how the lessons learnt in these studies compare and could be applied to all other eukaryotes. This article is part of a Special Issue entitled: Histone H1, edited by Dr. Albert Jordan. (C) 2015 Elsevier B.V. All rights reserved.

引用

页码：526 / 532

页数：7

共 60 条

[1]

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