The Suzuki homocoupling reaction under high-intensity ultrasound

被引：60

作者：

Cravotto, G

Palmisano, G

Tollari, S

Nano, GM

Penoni, A

机构：

[1] Univ Turin, Dipartimento Sci & Tecnol Farm, I-10125 Turin, Italy

[2] Univ Insubria, Dipartimento Sci Chim & Ambientali, I-22100 Como, Italy

来源：

ULTRASONICS SONOCHEMISTRY | 2005年 / 12卷 / 1-2期

关键词：

suzuki homocoupling; high-intensity ultrasound; reaction in water; biaryls; oxygen; 3-bromo-4-hydroxycoumarin;

D O I：

10.1016/j.ultsonch.2004.05.005

中图分类号：

O42 [声学];

学科分类号：

070206 ; 082403 ;

摘要：

The Pd-catalysed Suzuki homocoupling of boronic acids was successfully carried out in water under high-intensity ultrasound (HIU). Heterogeneous catalysis with Pd/C, facilitating work up and purification, could be used without adding phosphine ligands. Reaction rates and yields were strongly influenced by the oxidant employed; excellent results were obtained using either molecular oxygen or 3-bromo-4-hydroxycoumarin. 3-Arylation of the latter with the Suzuki procedure had failed, exclusively affording the homocoupling products, symmetric biaryls. Besides offering a number of operational advantages, the use of HIU broadens the field of application for the Suzuki reaction. (C) 2004 Elsevier B.V. All rights reserved.

引用

页码：91 / 94

页数：4

共 32 条

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