Formal synthesis of (+)-discodermolide

被引：39

作者：

Francavilla, C ^{[1
]}

Chen, WC ^{[1
]}

Kinder, FR ^{[1
]}

机构：

[1] Novartis Pharmaceut Corp, Oncol Res, Summit, NJ 07901 USA

来源：

ORGANIC LETTERS | 2003年 / 5卷 / 08期

关键词：

D O I：

10.1021/ol034186t

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Herein we report the formal total synthesis of (+)-discodermolide in 21 steps (longest linear sequence) from commercially available Roche ester. This synthesis features the assembly of C9-18 and C19-24 fragments via a metal-chelated aldol coupling reaction.

引用

页码：1233 / 1236

页数：4

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