The interactions of cobalt(II) with mitochondria from rat liver

被引：16

作者：

Bragadin, Marcantonio

Toninello, Antonio

Mancon, Mario

Manente, Sabrina

机构：

[1] Univ Ca Foscari, Dipartimento Sci Ambientali, I-30123 Venice, Italy

[2] Univ Padua, Dipartimento Chim Biol, I-35121 Padua, Italy

[3] CNR, Ctr Studio Biomembrane, I-35121 Padua, Italy

来源：

JOURNAL OF BIOLOGICAL INORGANIC CHEMISTRY | 2007年 / 12卷 / 05期

关键词：

cobalt; mitochondria; energy synthesis;

D O I：

10.1007/s00775-007-0222-1

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The interactions of Co2+ with mitochondria have been investigated. The results indicate that Co2+ inhibits ATP synthesis. Further investigations into ATP synthesis mechanisms indicated that inhibition is due to the opening of a transmembrane pore. The opening of this pore causes the collapse of the high-energy intermediate where, under a pH and a potential gradient, the energy is stored and subsequently utilized to form ATP from ADP.

引用

收藏

页码：631 / 635

页数：5

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