Characterization of the human gene coding for the swelling-dependent chloride channel ICln at position 11q13.5-14.1 (CLNS1A) and further characterization of the chromosome 6 (CLNS1B) localization

被引：5

作者：

Nagl, UO

Erdel, M

Bergmann, F

Oehl, B

Scandella, E

Musante, L

Galietta, LJV

Gschwentner, M

Fürst, J

Schmarda, A

Hofer, S

Utermann, G

Deetjen, P

Paulmichl, M

机构：

[1] Univ Innsbruck, Dept Physiol, A-6020 Innsbruck, Austria

[2] Univ Innsbruck, Dept Med Biol & Human Genet, A-6020 Innsbruck, Austria

[3] Ist Giannina Gaslini, Genet Mol Lab, I-16148 Genoa, Italy

来源：

GENE | 1998年 / 209卷 / 1-2期

基金：

奥地利科学基金会;

关键词：

I(Cln); swelling-dependent chloride channel; human chromosomal localization; RVD;

D O I：

10.1016/S0378-1119(98)00002-X

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

Expression cloning revealed a chloride channel (I(Cln)) that we found to be fundamental for the regulatory volume decrease in a variety of cells. The chromosomal localization of the human I(Cln)-gene showed two loci, one at chromosome 11 in position q13.5-q14.1, termed CLNS1A, and a second one at chromosome 6 at position p12.1-q13, termed CLNS1B. In this study, we offer a detailed characterization of the CLNS1A gene and provide the exact position (6p12) and sequence data of CLNS1B, an intronless gene 91.3% homologous to the coding region of CLNS1A. (C) 1998 Elsevier Science B.V.

引用

页码：59 / 63

页数：5

共 11 条

[1] MOLECULAR-CLONING OF THE HUMAN VOLUME-SENSITIVE CHLORIDE CONDUCTANCE REGULATORY PROTEIN, PICLN, FROM OCULAR CILIARY EPITHELIUM [J].