InBr3 as a versatile and highly efficient catalyst for the synthesis of 3-allyl- and 3-benzylindoles

被引：42

作者：

Yadav, J. S. ^{[1
]}

Reddy, B. V. Subba ^{[1
]}

Aravind, S. ^{[1
]}

Kumar, G. G. K. S. Narayana ^{[1
]}

Reddy, A. Srinivas ^{[1
]}

机构：

[1] Indian Inst Chem Technol, Div Organ Chem, Hyderabad 500007, Andhra Pradesh, India

来源：

TETRAHEDRON LETTERS | 2007年 / 48卷 / 35期

关键词：

indium reagents; benzylic/allylic alcohols; indoles; benzylation; allylation;

D O I：

10.1016/j.tetlet.2007.06.144

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Indoles undergo smooth alkylation with allylic and benzylic alcohols in the presence of 10 mol % of InBr3 under mild conditions to produce 3-allyl- and 3-benzyl indoles, respectively, in excellent yields and with high selectivity. This is the first example of the alkylation of indoles with benzylic alcohols using InBr3 as an acid catalyst. (c) 2007 Published by Elsevier Ltd.

引用

页码：6117 / 6120

页数：4

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