Gold nanoparticles inhibit the proliferation of multiple myeloma cells

被引：85

作者：

Bhattacharya, Resham

Patra, Chitta Ranjan

Verma, Rajanshu

Kumar, Shaji

Greipp, Philip R.

Mukherjee, Priyabrata ^{[1
]}

机构：

[1] Mayo Clin, Coll Med, Dept Biochem & Mol Biol, Rochester, MN 55905 USA

[2] Mayo Clin, Coll Med, Dept Biomed Engn, Rochester, MN 55905 USA

[3] Mayo Clin, Coll Med, Dept Hematol, Rochester, MN 55905 USA

来源：

ADVANCED MATERIALS | 2007年 / 19卷 / 05期

关键词：

D O I：

10.1002/adma.200602098

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Gold nanoparticles significantly inhibit proliferation in multiple myeloma cell lines (see figure) in a dose-dependent manner. Gold-treated multiple myeloma cells show cell-cycle arrest in the G1-phase (the phase when chromosomes prepare for replication) by up-regulation of cell-cycle cyclin-dependent kinase inhibitor proteins p21 and p27. Gold nanoparticles do not affect normal peripheral blood mononuclear cells.

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页码：711 / +

页数：7

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