The roles of p63 in cancer

被引:95
作者
Flores, Elsa R. [1 ]
机构
[1] Univ Texas, MD Anderson Canc Ctr, Dept Mol & Cellular Oncol, Grad Sch Biomed Sci, Houston, TX 77030 USA
关键词
tumor suppressor gene; oncogene; apoptosis; mouse models; DNA damage;
D O I
10.4161/cc.6.3.3793
中图分类号
Q2 [细胞生物学];
学科分类号
071009 ; 090102 ;
摘要
p63 plays an important role in skin and limb development. This has been clearly demonstrated using mouse models and from studies on human patients harboring p63 mutations. One question that remains unanswered is whether p63 is a tumor suppressor gene or an oncogene. The complexity of the study of p63 is due to the existence of multiple isoforms with opposing functions. The lack of antibodies that distinguish between these isoforms has made the ability to analyze the expression of p63 difficult in human tumors. Many studies have found that p63 is overexpressed in human tumors while other studies have shown a loss of expression of p63. Here, we review the roles of p63 in tumor development and suppression in mouse models and human tumors.
引用
收藏
页码:300 / 304
页数:5
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