A validated HPLC method for determination of Artesunate in bulk and tablet formulation

被引：9

作者：

Ranher, S. S. ^{[1
]}

Gandhi, S. V. ^{[1
]}

Kadukar, S. S. ^{[1
]}

Ranjane, P. N. ^{[1
]}

机构：

[1] AISSMS Coll Pharm, Dept Pharmaceut Anal, Pune 411001, Maharashtra, India

来源：

JOURNAL OF ANALYTICAL CHEMISTRY | 2010年 / 65卷 / 05期

关键词：

DRUG;

D O I：

10.1134/S1061934810050126

中图分类号：

O65 [分析化学];

学科分类号：

070302 [分析化学];

摘要：

The simple, accurate and precise HPLC method for determination of Artesunate in bulk and tablet dosage form has been developed. Quantitation of drug was carried out on Jasco HPLC system with HiQ-SiL C(8) column (250 mm x 4.6 mm i.d.), using acetonitrile: 1 M sodium acetate buffer (pH 3 adjusted with o-phosphoric acid) in the ratio 70: 30 as mobile phase. Method was developed using Artemether as internal standard and UV detector set at 220 nm. Linear concentration range was found to be 250-2500 mu g/mL. The method has been successfully applied to the analysis of drugs in bulk and pharmaceutical formulation. The method was validated with respect to linearity, precision and accuracy as per the International Conference on Harmonisation guidelines.

引用

页码：507 / 510

页数：4

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