Spotlights on advances in mycotoxin research

被引:11
作者
Bohnert, Markus [1 ]
Wackler, Barbara [1 ]
Hoffmeister, Dirk [1 ]
机构
[1] Univ Jena, Dept Pharmaceut Biol, Hans Knoll Inst, D-07745 Jena, Germany
关键词
Ascomycetes; Basidiomycetes; Biosynthesis; Genomics; Mycotoxin; Natural products; NONRIBOSOMAL PEPTIDE SYNTHETASE; IPOMOEA-ASARIFOLIA CONVOLVULACEAE; BIOSYNTHETIC GENE CLUSTERS; POLYKETIDE SYNTHASE GENES; ACTIVATED PROTEIN-KINASE; ASPERGILLUS-NIDULANS; SECONDARY METABOLISM; FUSARIUM-GRAMINEARUM; NATURAL-PRODUCTS; GLIOTOXIN PRODUCTION;
D O I
10.1007/s00253-010-2565-8
中图分类号
Q81 [生物工程学(生物技术)]; Q93 [微生物学];
学科分类号
071005 ; 0836 ; 090102 ; 100705 ;
摘要
A remarkable feature of filamentous fungi is their ability to produce small yet structurally complex and often bioactive natural products. In this mini-review, we cover advances in the research on fungal secondary metabolites, particularly mycotoxins, and focus on biosynthetic aspects as well as on the complex regulatory mechanisms which control the expression of biosynthetic genes. We also highlight the increasing impact of genomics and transcriptomics, which help explore the realm of secondary metabolism of fungi.
引用
收藏
页码:1 / 7
页数:7
相关论文
共 46 条
  • [11] Accurate prediction of the Aspergillus nidulans terrequinone gene cluster boundaries using the transcriptional regulator LaeA
    Bouhired, Sarah
    Weber, Monika
    Kempf-Sontag, Anita
    Keller, Nancy P.
    Hoffmeister, Dirk
    [J]. FUNGAL GENETICS AND BIOLOGY, 2007, 44 (11) : 1134 - 1145
  • [12] Twenty-five coregulated transcripts define a sterigmatocystin gene cluster in Aspergillus nidulans
    Brown, DW
    Yu, JH
    Kelkar, HS
    Fernandes, M
    Nesbitt, TC
    Keller, NP
    Adams, TH
    Leonard, TJ
    [J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1996, 93 (04) : 1418 - 1422
  • [13] Chiang YM, 2009, NAT PROD COMMUN, V4, P1505
  • [14] The Genome of Nectria haematococca: Contribution of Supernumerary Chromosomes to Gene Expansion
    Coleman, Jeffrey J.
    Rounsley, Steve D.
    Rodriguez-Carres, Marianela
    Kuo, Alan
    Wasmann, Catherine C.
    Grimwood, Jane
    Schmutz, Jeremy
    Taga, Masatoki
    White, Gerard J.
    Zhou, Shiguo
    Schwartz, David C.
    Freitag, Michael
    Ma, Li-jun
    Danchin, Etienne G. J.
    Henrissat, Bernard
    Coutinho, Pedro M.
    Nelson, David R.
    Straney, Dave
    Napoli, Carolyn A.
    Barker, Bridget M.
    Gribskov, Michael
    Rep, Martijn
    Kroken, Scott
    Molnar, Istvan
    Rensing, Christopher
    Kennell, John C.
    Zamora, Jorge
    Farman, Mark L.
    Selker, Eric U.
    Salamov, Asaf
    Shapiro, Harris
    Pangilinan, Jasmyn
    Lindquist, Erika
    Lamers, Casey
    Grigoriev, Igor V.
    Geiser, David M.
    Covert, Sarah F.
    Temporini, Esteban
    VanEtten, Hans D.
    [J]. PLOS GENETICS, 2009, 5 (08):
  • [15] Phylogenomic analysis of non-ribosomal peptide synthetases in the genus Aspergillus
    Cramer, Robert A., Jr.
    Stajich, Jason E.
    Yamanaka, Yvonne
    Dietrich, Fred S.
    Steinbach, William J.
    Perfect, John R.
    [J]. GENE, 2006, 383 : 24 - 32
  • [16] Disruption of a nonribosomal peptide synthetase in Aspergillus fumigatus eliminates gliotoxin production
    Cramer, Robert A., Jr.
    Gamcsik, Michael P.
    Brooking, Rhea M.
    Najvar, Laura K.
    Kirkpatrick, William R.
    Patterson, Thomas F.
    Balibar, Carl J.
    Graybill, John R.
    Perfect, John R.
    Abraham, Soman N.
    Steinbach, William J.
    [J]. EUKARYOTIC CELL, 2006, 5 (06) : 972 - 980
  • [17] From Yellow Rain to Green Wheat: 25 Years of Trichothecene Biosynthesis Research
    Desjardins, Anne E.
    [J]. JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY, 2009, 57 (11) : 4478 - 4484
  • [18] Production of the toxin sirodesmin PL by Leptosphaeria maculans during infection of Brassica napus
    Elliott, Candace E.
    Gardiner, Donald M.
    Thomas, Georgina
    Cozijnsen, Anton
    De Wouw, Angela Van
    Howlett, Barbara J.
    [J]. MOLECULAR PLANT PATHOLOGY, 2007, 8 (06) : 791 - 802
  • [19] Biosynthetic gene clusters for epipolythiodioxopiperazines in filamentous fungi
    Fox, Ellen M.
    Howlett, Barbara J.
    [J]. MYCOLOGICAL RESEARCH, 2008, 112 : 162 - 169
  • [20] Characterization of two polyketide synthase genes involved in zearalenone biosynthesis in Gibberella zeae
    Gaffoor, I
    Trail, F
    [J]. APPLIED AND ENVIRONMENTAL MICROBIOLOGY, 2006, 72 (03) : 1793 - 1799