A study of the immunological response to tumor ablation with irreversible Electroporation

被引：86

作者：

Al-Sakere, B.

Bernat, C.

Andr, F.

Connault, E.

Opolon, P.

Davalos, R. V.

Mir, L. M.

机构：

[1] Inst Gustave Roussy, CNRS, UMR 8121, F-94805 Villejuif, France

[2] Univ Paris Sud, UMR 8121, Paris, France

[3] Wake Forest Univ, Virginia Tech, Sch Biomed Engn & Sci, Blacksburg, VA 24061 USA

来源：

TECHNOLOGY IN CANCER RESEARCH & TREATMENT | 2007年 / 6卷 / 04期

关键词：

tumor ablation; irreversible electroporation; immunological response; tumor infiltration; and immunocytochemistry;

D O I：

10.1177/153303460700600406

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Immune cell recruitment during the treatment of sarcoma tumors in mice with irreversible electroporation was studied by immunohistochemistry. Irreversible electroporation is a non-thermal tissue ablation technique in which certain short duration electrical fields are used to permanently permeabilize the cell membrane, presumably through the formation of nanoscale defects in the membrane. Employing irreversible electroporation parameters known to completely ablate the tumors without thermal effects we did not find infiltration of immune cells probably because of the destruction of infiltration routes. We confirm here that immune response is not instrumental in irreversible electroporation efficacy, and we propose that irreversible electroporation may be, therefore, a treatment modality of interest to immunodepressed cancer patients.

引用

页码：301 / 305

页数：5