Natural Killer T Cells and Atherosclerosis: Form and Function Meet Pathogenesis

被引：28

作者：

Braun, Nicole A. ^{[2
]}

Covarrubias, Roman ^{[2
]}

Major, Amy S. ^{[1
,2
]}

机构：

[1] Vanderbilt Univ, Med Ctr, Dept Med, Div Cardiovasc Med, Nashville, TN 37232 USA

[2] Vanderbilt Univ, Med Ctr, Dept Mol Pathol, Nashville, TN 37232 USA

来源：

JOURNAL OF INNATE IMMUNITY | 2010年 / 2卷 / 04期

关键词：

Adaptive immunity; Atherosclerosis; Chronic inflammation; Dyslipidemia; Immune regulation; Innate immunity; Natural killer T cells; LOW-DENSITY-LIPOPROTEIN; E-DEFICIENT MICE; CORONARY-ARTERY-DISEASE; INVARIANT NKT CELLS; RECEPTOR-NULL MICE; OXIDIZED LDL; AUTOIMMUNE ENCEPHALOMYELITIS; BETA(2)-GLYCOPROTEIN I; PROTECTIVE IMMUNITY; MEDIATED ACTIVATION;

D O I：

10.1159/000296915

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Atherosclerosis is a chronic inflammatory disease characterized by dyslipidemia and accumulation of lipids in the arterial intima, with activation of both innate and adaptive immunity. Reciprocally, dyslipidemia associated with atherosclerosis can perturb normal immune function. Natural killer T (NKT) cells are a specialized group of immune cells that share characteristics with both conventional T cells and natural killer cells. However, unlike these cells, NKT cells recognize glycolipid antigens and produce both pro- and anti-inflammatory cytokines upon activation. Because of these unique characteristics, NKT cells have recently been ascribed a role in the regulation of immunity and inflammation, including cardiovascular disease. In addition, NKT cells represent a bridge between dyslipidemia and immune regulation. This review summarizes the current knowledge of NKT cells and discusses the interplay between dyslipidemia and the normal functions of NKT cells and how this might modulate inflammation and atherosclerosis. Copyright (C) 2010 S. Karger AG, Basel

引用

页码：316 / 324

页数：9

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