A brief history of the randomized controlled trial - From oranges and lemons to the gold standard

被引:120
作者
Meldrum, ML [1 ]
机构
[1] Natl Inst Dent & Craniofacial Res, Pain & Neurosensory Mechanisms Branch, NIH, Bethesda, MD USA
关键词
D O I
10.1016/S0889-8588(05)70309-9
中图分类号
R73 [肿瘤学];
学科分类号
100214 ;
摘要
This article discusses the history and development of randomized clinical trial methodology, the reasons for its status and authority as a method of therapeutic evaluation, and the continuing role of clinical judgement in designing, interpreting, and applying the findings of trials.
引用
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页码:745 / +
页数:17
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