Hedgehogs and retinal ganglion cells: organizers of the mammalian retina

被引：20

作者：

Dakubo, GD

Wallace, VA

机构：

[1] Ottawa Hlth Res Inst, Program Mol Med, Ottawa, ON, Canada

[2] Univ Ottawa, Dept Biochem Microbiol & Immunol, Ottawa, ON K1H 8M5, Canada

来源：

NEUROREPORT | 2004年 / 15卷 / 03期

关键词：

differentiation; Hedgehog genes; laminar organization; progenitor cells; proliferation; retina;

D O I：

10.1097/00001756-200403010-00019

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

The mature vertebrate retina develops from a population of multipotential neural progenitor cells that give rise to all of the retinal neurons and one glial cell type. Retinal histogenesis is regulated, in part, by cell extrinsic cues. A growing number of studies now implicate signaling by members of the Hedgehog (Hh) family of morphogens in vertebrate retinal development. In this review we will discuss the role of Hh signals from retinal ganglion cells (RGCs), the projection neurons of the retina, on proliferation, differentiation and lamination in the neural retina.

引用

收藏

页码：479 / 482

页数：4

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