Formation and regulation of lipid microdomains in cell membranes: Theory, modeling, and speculation

被引：86

作者：

Fan, Jun ^{[1
]}

Sammalkorpi, Maria ^{[1
]}

Haataja, Mikko ^{[1
]}

机构：

[1] Princeton Univ, Program Appl & Computat Math, Princeton Inst Sci & Technol Mat, Dept Mech & Aerosp Engn, Princeton, NJ 08544 USA

来源：

FEBS LETTERS | 2010年 / 584卷 / 09期

关键词：

Cell membrane; Lipid microdomain; Theory; Modeling; PLASMA-MEMBRANE; PHASE-SEPARATION; LATERAL DIFFUSION; RAFTS; DOMAINS; PROTEINS; DYNAMICS; MIXTURES; STATE;

D O I：

10.1016/j.febslet.2009.10.051

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Compositional lipid microdomains ("lipid raft") in plasma membranes are believed to be important components of many cellular processes. The biophysical mechanisms by which cells regulate the size, lifetime, and spatial localization of these domains are rather poorly understood at the moment. Over the years, experimental studies of raft formation have inspired several phenomenological theories and speculations incorporating a wide variety of thermodynamic assumptions regarding lipid-lipid and lipid-protein interactions, and the potential role of active cellular processes on membrane structure. Here we critically review and discuss these theories, models, and speculations, and present our view on future directions. (C) 2009 Federation of European Biochemical Societies. Published by Elsevier B. V. All rights reserved.

引用

页码：1678 / 1684

页数：7

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