Pd-catalyzed cascade carbopalladation-annulation reaction of 3-(2-iodobenzyl)-indoles into fused 6/5/7/6-and 6/5/5/6-heterocyclic systems

被引：60

作者：

Chernyak, Natalia ^{[1
]}

Tilly, David ^{[1
]}

Li, Zhou ^{[1
]}

Gevorgyan, Vladimir ^{[1
]}

机构：

[1] Univ Illinois, Dept Chem, Chicago, IL 60607 USA

来源：

CHEMICAL COMMUNICATIONS | 2010年 / 46卷 / 01期

基金：

美国国家卫生研究院;

关键词：

ROOM-TEMPERATURE; DIRECT ARYLATION; CYCLIZATION; HETEROCYCLES; ALKALOIDS; MECHANISM; INDOLES; ROUTE;

D O I：

10.1039/b919991h

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Polycyclic indole structures, possessing fused seven-membered rings were efficiently synthesized via the Pd-catalyzed intramolecular carbopalladation-annulation of 3-(2-iodobenzyl)-indoles and alkynes. A remarkable base effect on the chemoselectivity of this transformation has been found: switching from Et3N to CsOAc completely reverses the reaction path to intramolecular cyclization forming fused five-membered rings.

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收藏

页码：150 / 152

页数：3

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