AKAP79 and the evolution of the AKAP model

被引：110

作者：

Dodge, K ^{[1
]}

Scott, JD ^{[1
]}

机构：

[1] Oregon Hlth Sci Univ, Vollum Inst, Howard Hughes Med Inst, Portland, OR 97201 USA

来源：

FEBS LETTERS | 2000年 / 476卷 / 1-2期

关键词：

D O I：

10.1016/S0014-5793(00)01671-9

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

A molecular explanation for the specificity of the cAMP-dependent protein kinase (PKA) can be provided by its compartmentalization through association with A-kinase-anchoring proteins (AKAPs), Structural and functional studies have led to the development of an anchoring model proposing that AKAPs contain a common PKA binding domain and a unique subcellular targeting domain. The discovery that AKAPs can bind other signaling enzymes led to the addition of a third property, that of scaffolding molecule. Recent research has now expanded the role of AKAPs to members of multiunit complexes containing both upstream activators and downstream targets. (C) 2000 Federation of European Biochemical Societies, Published by Elsevier Science B.V. All rights reserved.

引用

页码：58 / 61

页数：4

共 46 条

[11] ASSOCIATION OF PROTEIN-KINASE-A AND PROTEIN-PHOSPHATASE-2B WITH A COMMON ANCHORING PROTEIN
COGHLAN, VM
PERRINO, BA
HOWARD, M
LANGEBERG, LK
HICKS, JB
GALLATIN, WM
SCOTT, JD
[J]. SCIENCE, 1995, 267 (5194) : 108 - 111
[12] COLLEDGE M, 1999, SOC NEUROSCI, V25, P1320
[13] COLLEDGE M, 2000, IN PRESS NEURON
[14] CORBIN JD, 1977, J BIOL CHEM, V252, P3854
[15] Receptor and G beta gamma isoform-specific interactions with G protein-coupled receptor kinases
Daaka, Y
Pitcher, JA
Richardson, M
Stoffel, RH
Robishaw, JD
Lefkowitz, RJ
[J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1997, 94 (06) : 2180 - 2185
[16] Membrane-targeting sequences on AKAP79 bind phosphatidylinositol-4,5-bisphosphate
Dell'Acqua, ML
Faux, MC
Thorburn, J
Thorburn, A
Scott, JD
[J]. EMBO JOURNAL, 1998, 17 (08) : 2246 - 2260
[17] Protein kinase A anchoring to the myometrial plasma membrane is required for cyclic adenosine 3′,5′-monophosphate regulation of phosphatidylinositide turnover
Dodge, KL
Carr, DW
Sanborn, BM
[J]. ENDOCRINOLOGY, 1999, 140 (11) : 5165 - 5170
[18] A role for AKAP (a kinase anchoring protein) scaffolding in the loss of a cyclic adenosine 3′,5′-monophosphate inhibitory response in late pregnant rat myometrium
Dodge, KL
Carr, DW
Yue, CP
Sanborn, BM
[J]. MOLECULAR ENDOCRINOLOGY, 1999, 13 (12) : 1977 - 1987
[19] Mechanism of A-kinase-anchoring protein 79 (AKAP79) and protein kinase C interaction
Faux, MC
Rollins, EN
Edwards, AS
Langeberg, LK
Newton, AC
Scott, JD
[J]. BIOCHEMICAL JOURNAL, 1999, 343 : 443 - 452
[20] Regulation of the AKAP79-protein kinase C interaction by Ca2+/calmodulin
Faux, MC
Scott, JD
[J]. JOURNAL OF BIOLOGICAL CHEMISTRY, 1997, 272 (27) : 17038 - 17044

← 1 2 3 4 5 →