Evolutionary divergence of substrate specificity within the chymotrypsin-like serine protease fold

被引：297

作者：

Perona, JJ

Craik, CS

机构：

[1] UNIV CALIF SANTA BARBARA, INTERDEPT PROGRAM BIOCHEM & MOL BIOL, SANTA BARBARA, CA 93106 USA

[2] UNIV CALIF SAN FRANCISCO, DEPT PHARMACEUT CHEM, SAN FRANCISCO, CA 94143 USA

来源：

JOURNAL OF BIOLOGICAL CHEMISTRY | 1997年 / 272卷 / 48期

关键词：

D O I：

10.1074/jbc.272.48.29987

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

引用

页码：29987 / 29990

页数：4

共 36 条

[1] Understanding enzyme superfamilies - Chemistry as the fundamental determinant in the evolution of new catalytic activities [J].

Babbitt, PC ;

Gerlt, JA .

JOURNAL OF BIOLOGICAL CHEMISTRY, 1997, 272 (49) :30591-30594

[2] STEPWISE IMPROVEMENTS IN CATALYTIC EFFECTIVENESS - INDEPENDENCE AND INTERDEPENDENCE IN COMBINATIONS OF POINT MUTATIONS OF A SLUGGISH TRIOSEPHOSPHATE ISOMERASE [J].

BLACKLOW, SC ;

LIU, KD ;

KNOWLES, JR .

BIOCHEMISTRY, 1991, 30 (34) :8470-8476

[3] THE REFINED 1.9 A CRYSTAL-STRUCTURE OF HUMAN ALPHA-THROMBIN - INTERACTION WITH D-PHE-PRO-ARG CHLOROMETHYLKETONE AND SIGNIFICANCE OF THE TYR-PRO-PRO-TRP INSERTION SEGMENT [J].

BODE, W ;

MAYR, I ;

BAUMANN, U ;

HUBER, R ;

STONE, SR ;

HOFSTEENGE, J .

EMBO JOURNAL, 1989, 8 (11) :3467-3475

[4] STRUCTURAL PLASTICITY BROADENS THE SPECIFICITY OF AN ENGINEERED PROTEASE [J].

BONE, R ;

SILEN, JL ;

AGARD, DA .

NATURE, 1989, 339 (6221) :191-195

[5] SERINE PROTEASE MECHANISM - STRUCTURE OF AN INHIBITORY COMPLEX OF ALPHA-LYTIC PROTEASE AND A TIGHTLY BOUND PEPTIDE BORONIC ACID [J].

BONE, R ;

SHENVI, AB ;

KETTNER, CA ;

AGARD, DA .

BIOCHEMISTRY, 1987, 26 (24) :7609-7614

[6] Structure of the human cytomegalovirus protease catalytic domain reveals a novel serine protease fold and catalytic triad [J].

Chen, P ;

Tsuge, H ;

Almassy, RJ ;

Gribskov, CL ;

Katoh, S ;

Vanderpool, DL ;

Margosiak, SA ;

Pinko, C ;

Matthews, DA ;

Kan, CC .

CELL, 1996, 86 (05) :835-843

[7] A HIGHLY-ACTIVE DECARBOXYLATING DEHYDROGENASE WITH RATIONALLY INVERTED COENZYME SPECIFICITY [J].

CHEN, RD ;

GREER, A ;

DEAN, AM .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1995, 92 (25) :11666-11670

[8] AN ALTERNATE GEOMETRY FOR THE CATALYTIC TRIAD OF SERINE PROTEASES [J].

COREY, DR ;

MCGRATH, ME ;

VASQUEZ, JR ;

FLETTERICK, RJ ;

CRAIK, CS .

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 1992, 114 (12) :4905-4907

[9] REDESIGNING TRYPSIN - ALTERATION OF SUBSTRATE-SPECIFICITY [J].

CRAIK, CS ;

LARGMAN, C ;

FLETCHER, T ;

ROCZNIAK, S ;

BARR, PJ ;

FLETTERICK, R ;

RUTTER, WJ .

SCIENCE, 1985, 228 (4697) :291-297

[10] SUBSTRATE-SPECIFICITY OF TRYPSIN INVESTIGATED BY USING A GENETIC SELECTION [J].

EVNIN, LB ;

VASQUEZ, JR ;

CRAIK, CS .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1990, 87 (17) :6659-6663

← 1 2 3 4 →