Self-assembly of small peptidomimetic cyclophanes

被引：68

作者：

Becerril, J

Burguete, MI

Escuder, B ^{[1
]}

Galindo, F

Gavara, R

Miravet, JF

Luis, SV

Peris, G

机构：

[1] Univ Jaume 1, Dept Quim Inorgan & Organ, Castellon de La Plana 12071, Spain

[2] Univ Jaume 1, Serv Cent Instrumentacio Cien, Castellon de La Plana 12071, Spain

来源：

CHEMISTRY-A EUROPEAN JOURNAL | 2004年 / 10卷 / 16期

关键词：

gels; helical structures; peptidomimetics; self-assembly; supramolecular chemistry;

D O I：

10.1002/chem.200400031

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

The self-assembly of a series of small peptidomimetic cyclophanes in organic solvents was studied. X-ray diffraction, NMR spectroscopy, and molecular modelling were used to understand the structural features of these self-assembling compounds both at the molecular and supramolecular level. The factors that could influence the formation of gels rather than crystals were studied and a model for the arrangement of molecules in the gel was proposed. Furthermore, scanning electron microscopy revealed that in some cases these compounds undergo a transcription of chirality when going from organogelator to helicoidal gel fibres.

引用

页码：3879 / 3890

页数：12

共 110 条

[11] Efficient macrocyclization of U-turn preorganized peptidomimetics:: The role of intramolecular H-bond and solvophobic effects [J].