The EGF-CFC gene family in vertebrate development

被引：177

作者：

Shen, MM

Schier, AF

机构：

[1] Univ Med & Dent New Jersey, Robert Wood Johnson Med Sch, Ctr Adv Biotechnol & Med, Piscataway, NJ 08854 USA

[2] Univ Med & Dent New Jersey, Robert Wood Johnson Med Sch, Dept Pediat, Piscataway, NJ 08854 USA

[3] NYU, Sch Med, Dept Cell Biol, Skirball Inst Biomol Med,Dev Genet Program, New York, NY 10016 USA

来源：

TRENDS IN GENETICS | 2000年 / 16卷 / 07期

基金：

美国国家卫生研究院;

关键词：

D O I：

10.1016/S0168-9525(00)02006-0

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

EGF-CFC genes encode extracellular proteins that play key roles in intercellular signaling pathways during vertebrate embryogenesis. Mutations in zebrafish and mouse EGF-CFC genes lead to defects in germ-layer formation, anterior-posterior axis orientation and left-right axis specification. In addition, members of the EGF-CFC family have been implicated in carcinogenesis. Although formerly regarded as signaling molecules that are distant relatives of epidermal growth factor (EGF), recent findings indicate that EGF-CFC proteins act as essential cofactors for Nodal, a member of the transforming growth factor beta (TGF-beta) family. Here, we review molecular genetic evidence from mouse and zebrafish on biological and biochemical roles of the EGF-CFC family, and discuss differing models for EGF-CFC protein function.

引用

收藏

页码：303 / 309

页数：7

相关论文

共 54 条

[21] GDNF-induced activation of the Ret protein tyrosine kinase is mediated by GDNFR-alpha, a novel receptor for GDNF [J].

Jing, SQ ;

Wen, DZ ;

Yu, YB ;

Holst, PL ;

Luo, Y ;

Fang, M ;

Tamir, R ;

Antonio, L ;

Hu, Z ;

Cupples, R ;

Louis, JC ;

Hu, S ;

Altrock, BW ;

Fox, GM .

CELL, 1996, 85 (07) :1113-1124

[22] Cripto enhances the tyrosine phosphorylation of Shc and activates mitogen-activated protein kinase (MAPK) in mammary epithelial cells [J].

Kannan, S ;

DeSantis, M ;

Lohmeyer, M ;

Riese, DJ ;

Smith, GH ;

Hynes, N ;

Seno, M ;

Brandt, R ;

Bianco, C ;

Persico, G ;

Kenney, N ;

Normanno, N ;

MartinezLacaci, I ;

Ciardiello, F ;

Stern, DF ;

Gullick, WJ ;

Salomon, DS .

JOURNAL OF BIOLOGICAL CHEMISTRY, 1997, 272 (06) :3330-3335

[23] THE IDENTIFICATION OF 2 NOVEL LIGANDS OF THE FGF RECEPTOR BY A YEAST SCREENING METHOD AND THEIR ACTIVITY IN XENOPUS DEVELOPMENT [J].

KINOSHITA, N ;

MINSHULL, J ;

KIRSCHNER, MW .

CELL, 1995, 83 (04) :621-630

[24] A mechanism of repression of TGFβ/Smad signaling by oncogenic Ras [J].

Kretzschmar, M ;

Doody, J ;

Timokhina, I ;

Massagué, J .

GENES & DEVELOPMENT, 1999, 13 (07) :804-816

[25] A MOLECULAR PATHWAY DETERMINING LEFT-RIGHT ASYMMETRY IN CHICK EMBRYOGENESIS [J].

LEVIN, M ;

JOHNSON, RL ;

STERN, CD ;

KUEHN, M ;

TABIN, C .

CELL, 1995, 82 (05) :803-814

[26] Chemical synthesis, structural modeling, and biological activity of the epidermal growth factor-like domain of human Cripto [J].

Lohmeyer, M ;

Harrison, PM ;

Kannan, S ;

DeSantis, M ;

OReilly, NJ ;

Sternberg, MJE ;

Salomon, DS ;

Gullick, WJ .

BIOCHEMISTRY, 1997, 36 (13) :3837-3845

[27] Conserved left-right asymmetry of nodal expression and alterations in murine situs inversus [J].

Lowe, LA ;

Supp, DM ;

Sampath, K ;

Yokoyama, T ;

Wright, CVE ;

Potter, SS ;

Overbeek, P ;

Kuehn, MR .

NATURE, 1996, 381 (6578) :158-161

[28] TGF-β signal transduction [J].

Massagué, J .

ANNUAL REVIEW OF BIOCHEMISTRY, 1998, 67 :753-791

[29] Membrane-anchorage of Cripto protein by glycosylphosphatidylinositol and its distribution during early mouse development [J].

Minchiotti, G ;

Parisi, S ;

Liguori, G ;

Signore, M ;

Lania, G ;

Adamson, ED ;

Lago, CT ;

Persico, MG .

MECHANISMS OF DEVELOPMENT, 2000, 90 (02) :133-142

[30] The signaling pathway mediated by the type IIB activin receptor controls axial patterning and lateral asymmetry in the mouse [J].

Oh, SP ;

Li, E .

GENES & DEVELOPMENT, 1997, 11 (14) :1812-1826

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