Th1/Th2 cytokine profiles in the nasopharyngeal lymphoid tissues of children with recurrent otitis media

被引:25
作者
Bernstein, JM
Ballow, M
Xiang, SN
O'Neil, K
机构
[1] SUNY Buffalo, Childrens Hosp, Sch Med & Biomed Sci, Dept Otolaryngol, Buffalo, NY 14260 USA
[2] SUNY Buffalo, Childrens Hosp, Sch Med & Biomed Sci, Dept Pediat,Div Allergy & Clin Immunol, Buffalo, NY 14260 USA
关键词
adenoid; cytokine; Th1; Th2;
D O I
10.1177/000348949810700105
中图分类号
R76 [耳鼻咽喉科学];
学科分类号
100213 ;
摘要
The cytokine profile in adenoidal lymphoid tissue was studied in 22 patients. Lymphocytes from adenoid tissues and peripheral blood were submitted for cytokine assays using an enzyme-linked immunosorbent assay kit for interferon-gamma, interleukin (IL)-2, IL-4, IL-5, IL-6, and IL-10. Adenoidal lymphocytes appear to produce significantly less Th1 cytokines (IL-2, interferon gamma) compared to the patient's peripheral blood lymphocytes, whereas IL-4 and IL-5 (Th2 cytokines) appear to be synthesized to the same extent as if not slightly more than, in the homologous peripheral blood lymphocytes. Because the relationship between Th1 and Th2 cytokines is extremely important in modulating the immune response, it is advisable to determine the role of the cytokine profiles of T-lymphocytes in the nasopharynx and its relationship to the development of inflammation of the eustachian tube and middle ear.
引用
收藏
页码:22 / 27
页数:6
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