Rupture of Vulnerable Atherosclerotic Plaques: MicroRNAs Conducting the Orchestra?

被引：40

作者：

Haver, Vincent G. ^{[1
]}

Slart, Riemer H. J. A. ^{[1
]}

Zeebregts, Clark J. ^{[1
]}

Peppelenbosch, Maikel P. ^{[2
]}

Tio, Rene A. ^{[1
]}

机构：

[1] Univ Groningen, Univ Med Ctr Groningen, Cardiovasc Imaging Grp Groningen, NL-9713 GZ Groningen, Netherlands

[2] Erasmus MC, Dept Gastroenterol & Hepatol, Rotterdam, Netherlands

来源：

TRENDS IN CARDIOVASCULAR MEDICINE | 2010年 / 20卷 / 02期

关键词：

IN-VIVO; EXPRESSION; CELL; RNA; APOPTOSIS; RECEPTOR; CANCER; METASTASIS; INVASION; BIOLOGY;

D O I：

10.1016/j.tcm.2010.04.002

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

MicroRNAs (miRNAs) are tiny, endogenous nucleotides that bind to mRNA and induce translation repression within metazoan cells. Since their discovery in 1993 in Caenorhabditis elegans and the demonstration of miRNAs in Homo sapiens in 2000, research has been fruitful in deciphering the role of these nucleotides in development, tissue homeostasis, and pathologic processes. In humans, around 700 human miRNA nucleotides have been verified, which interfere with 30% of all genes. Recently, the role of miRNA in cardiovascular research gained attention and the involvement of miRNAs in several cardiovascular diseases has been identified. In this review, we focus on the role of miRNAs in atherosclerosis and in particular on the potential role of miRNAs in the development of vulnerable atherosclerotic plaques. The role of miRNA in the main characteristics of these plaques, inflammation, angiogenesis, and apoptosis will be discussed. Finally, the future perspectives and miRNA-based diagnostic and therapeutic potentials will be highlighted. (Trends Cardiovasc Med 2010;20:65-71) (c) 2010, Elsevier Inc.

引用

页码：65 / 71

页数：7

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