Hormonal regulation of radioiodide uptake activity and Na+/I- symporter expression in mammary glands

被引:96
作者
Cho, JY
Léveillé, R
Kao, R
Rousset, B
Parlow, AF
Burak, WE
Mazzaferri, EL
Jhiang, SM
机构
[1] Ohio State Univ, Coll Med, Dept Physiol & Cell Biol, Columbus, OH 43210 USA
[2] Ohio State Univ, Coll Med, Dept Surg, Columbus, OH 43210 USA
[3] Ohio State Univ, Dept Vet Clin Sci, Columbus, OH 43210 USA
[4] Fac Med Lyon RTH Laennec, INSERM, F-69372 Lyon, France
[5] Univ Calif Los Angeles, Los Angeles Cty Harbor Med Ctr, Res & Educ Inst, Natl Hormone & Pituitary Program, Torrance, CA 90502 USA
关键词
D O I
10.1210/jc.85.8.2936
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
The observation that radioiodide uptake (RAIU) activity, mediated by the Na+/I- symporter (NIS), is significantly increased in lactating breast suggests that RAIU and NIS expression in mammary gland are modulated by hormones involved in active lactation. We showed that both the NIS expression level and RAIU in rat mammary gland are maximal during active lactation compared to those in the mammary glands of virgin and pregnant rats as well as the involuting mammary gland. In the lactating mammary gland, NIS is clustered on the basolateral membrane of alveolar cells as a lesser glycosylated form than NIS in thyroid. The RAIU of lactating mammary gland was partially inhibited by treatment with a selective oxytocin antagonist or bromocriptine, an inhibitor of PRL release. These findings suggest that RAIU and NIS expression in mammary gland are at least in part modulated by oxytocin and PRL. Indeed, we showed that NIS messenger ribonucleic acid level was increased in a dose-dependent manner by oxytocin and PRL in histocultured human breast tumors.
引用
收藏
页码:2936 / 2943
页数:8
相关论文
共 28 条
[11]   Investigation of the oxytocin receptor expression in human breast cancer tissue using newly established monoclonal antibodies [J].
Ito, Y ;
Kobayashi, T ;
Kimura, T ;
Matsuura, N ;
Wakasugi, E ;
Takeda, T ;
Shimano, T ;
Kubota, Y ;
Nobunaga, T ;
Makino, Y ;
Azuma, C ;
Saji, F ;
Monden, M .
ENDOCRINOLOGY, 1996, 137 (02) :773-779
[12]   An immunohistochemical study of Na+/I- symporter in human thyroid tissues and salivary gland tissues [J].
Jhiang, SM ;
Cho, JY ;
Ryu, KY ;
DeYoung, BR ;
Smanik, PA ;
McGaughy, VR ;
Fischer, AH ;
Mazzaferri, EL .
ENDOCRINOLOGY, 1998, 139 (10) :4416-4419
[13]   Protein kinase A mediated inhibition of gamma interferon-induced tyrosine phosphorylation of Janus kinases and latent cytoplasmic transcription factors in human monocytes by Ehrlichia chaffeensis [J].
Lee, EH ;
Rikihisa, Y .
INFECTION AND IMMUNITY, 1998, 66 (06) :2514-2520
[14]  
MANNING M, 1995, INT J PEPT PROT RES, V46, P244
[15]   INVITRO UPTAKE OF I-131 BY MAMMARY TISSUE [J].
MAQSOOD, M ;
REINEKE, EP .
AMERICAN JOURNAL OF PHYSIOLOGY, 1960, 199 (05) :829-832
[16]  
Mazzaferi E. L., 1996, WERNER INGBARS THYRO, V7th, P922
[17]  
MORRISON LE, 1992, DETECTION ENERGY TRA
[18]   Characterization of the rat thyroid iodide transporter using anti-peptide antibodies - Relationship between its expression and activity [J].
Paire, A ;
BernierValentin, F ;
SelmiRuby, S ;
Rousset, B .
JOURNAL OF BIOLOGICAL CHEMISTRY, 1997, 272 (29) :18245-18249
[19]   Expression of prolactin and its receptor in human breast carcinoma [J].
Reynolds, C ;
Montone, KT ;
Powell, CM ;
Tomaszewski, JE ;
Clevenger, CV .
ENDOCRINOLOGY, 1997, 138 (12) :5555-5560
[20]   Prolactin stimulation of iodide uptake into mouse mammary gland explants [J].
Rillema, JA ;
Yu, TX .
AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM, 1996, 271 (05) :E879-E882