How melanoma cells evade trail-induced apoptosis

被引：177

作者：

Hersey, P ^{[1
]}

Zhang, XD ^{[1
]}

机构：

[1] Immunol & Oncol Unit, Newcastle, NSW 2300, Australia

来源：

NATURE REVIEWS CANCER | 2001年 / 1卷 / 02期

关键词：

D O I：

10.1038/35101078

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

At the doses used clinically, chemotherapy is believed to kill melanoma by a final common 'mitochondrial' pathway that leads to apoptosis. Similarly, several natural defence mechanisms kill melanoma by the same pathways. A corollary to the latter is that survival of melanoma in the host is due to the development of anti-apoptotic mechanisms in melanoma cells. What are these mechanisms? And how might we bypass them to improve the treatment of melanoma?.

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页码：142 / 150

页数：9

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